SCHEMBL6151507

SCHEMBL6151507

CCC12CC(=O)C=C1c1ccc(O)c(Cl)c1CC2Br

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 7/20 0.36
ESR1 P03372 5/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6150761 0.89 ESR2 (0.40) ESR2ESR1
SCHEMBL6151832 0.79 ESR2 (0.53) ESR2ESR1
SCHEMBL6136865 0.71 ESR2 (0.38) ESR2ESR1
SCHEMBL6150947 0.69 ESR2 (0.38) ESR2ESR1
SCHEMBL6150789 0.68 ESR2 (0.52) ESR2ESR1
SCHEMBL14473536 0.65 ESR2 (0.49) ESR2ESR1
SCHEMBL6150771 0.63 ESR2 (0.55) ESR2ESR1
SCHEMBL4802173 0.62 ESR1 (0.37) ESR2ESR1
SCHEMBL5905526 0.62 ESR1 (0.37) ESR2ESR1
SCHEMBL14473531 0.62 MEN1 (0.33) ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1551820-A2 ESTROGEN RECEPTOR MODULATORS Merck & Co., Inc. (US) 2005-07-13 EP claimed
WO-2004026887-A2 ESTROGEN RECEPTOR MODULATORS MERCK & CO., INC. (US) 2004-04-01 WO claimed