Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 | P02708 | 7/20 | 0.37 |
| ▸ | CHRNB1 | P11230 | 7/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 7/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 7/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.37 |
| ▸ | CHRNG | P07510 | 5/20 | 0.37 |
| ▸ | CHRND | Q07001 | 5/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152564 | 0.82 | PTGER2 (0.31) | SYKKCNH2 | |
| SCHEMBL6153490 | 0.80 | ELANE (0.32) | SLC6A2SLC6A3SLC6A4SYKKCNH2 | |
| SCHEMBL6152452 | 0.79 | PHGDH (0.37) | CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL6152473 | 0.78 | KCNH2 (0.36) | SLC6A2SLC6A3SLC6A4CTSKSYK | |
| SCHEMBL5773915 | 0.77 | HSD11B1 (0.43) | CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL5775507 | 0.77 | HSD11B1 (0.38) | CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL5775758 | 0.77 | HSD11B1 (0.38) | CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL5773782 | 0.74 | HSD11B1 (0.36) | CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL5774683 | 0.73 | HSD11B1 (0.38) | CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL6153194 | 0.69 | DDB1 (0.47) | CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6943181-B2 | Use of substituted gamma-lactone compounds as pharmaceutical preparations | GRUNENTHAL GMBH (DE) | 2005-09-13 | — | — | US | claimed |
| EP-1406610-B1 | USE OF SUBSTITUTED GAMMA-LACTONE COMPOUNDS AS MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2005-01-26 | — | — | EP | claimed |
| US-20040176394-A1 | Use of substituted gamma-lactone compounds as pharmaceutical preparations | GRUNENTHAL GMBH (DE) | 2004-09-09 | — | — | US | claimed |
| EP-1406610-A1 | USE OF SUBSTITUTED GAMMA-LACTONE COMPOUNDS AS MEDICAMENTS | Grünenthal GmbH (DE) | 2004-04-14 | — | — | EP | claimed |
| WO-2003004016-A1 | USE OF SUBSTITUTED GAMMA-LACTONE COMPOUNDS AS MEDICAMENTS | Grünenthal GmbH (DE) | 2003-01-16 | — | — | WO | claimed |
| US-6943181-B2 | Use of substituted gamma-lactone compounds as pharmaceutical preparations | GRUNENTHAL GMBH (DE) | 2005-09-13 | — | — | US | disclosed |
| EP-1406610-B1 | USE OF SUBSTITUTED GAMMA-LACTONE COMPOUNDS AS MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2005-01-26 | — | — | EP | disclosed |
| US-20040176394-A1 | Use of substituted gamma-lactone compounds as pharmaceutical preparations | GRUNENTHAL GMBH (DE) | 2004-09-09 | — | — | US | disclosed |
| EP-1406610-A1 | USE OF SUBSTITUTED GAMMA-LACTONE COMPOUNDS AS MEDICAMENTS | Grünenthal GmbH (DE) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003004016-A1 | USE OF SUBSTITUTED GAMMA-LACTONE COMPOUNDS AS MEDICAMENTS | Grünenthal GmbH (DE) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176394-A1 | Use of substituted gamma-lactone compounds as pharmaceutical preparations | BACE1, MYC, APP | CHRNA1 2150/4885CHRNB1 2607/4885CHRNB2 2376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.