Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 3/20 | 0.35 |
| ▸ | PPARD | Q03181 | 9/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 7/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152050 | 0.89 | PPARD (0.34) | TOP2ACTSSPPARDTP53MPO | |
| SCHEMBL5904881 | 0.87 | FFAR4 (0.40) | PPARDPPARAPPARG | |
| SCHEMBL5904913 | 0.85 | PPARD (0.53) | PPARDPPARAPPARG | |
| SCHEMBL6151357 | 0.84 | CTSS (0.33) | TOP2ACTSSPPARDPPARA | |
| SCHEMBL5904742 | 0.76 | NOTUM (0.43) | CTSSKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL6151361 | 0.74 | CTSS (0.32) | CTSSPPARDPPARAKDM4E | |
| SCHEMBL5904750 | 0.72 | PPARD (0.49) | PPARD | |
| SCHEMBL5904676 | 0.72 | PPARD (0.39) | PPARDPPARAPPARG | |
| SCHEMBL5904772 | 0.72 | FFAR1 (0.53) | PPARDPPARAPPARG | |
| SCHEMBL6152047 | 0.71 | PPARD (0.36) | TOP2APPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585733-A1 | HETEROCYCLIC PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063166-A1 | HETEROCYCLIC PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |