SCHEMBL6152137

SCHEMBL6152137

CCCCc1cc2cc(C(=O)O)ccc2[nH]1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.53
MPL P40238 3/20 0.47
RARB P10826 2/20 0.45
MTNR1A P48039 2/20 0.45
KDM4E B2RXH2 3/20 0.44
PPARG P37231 1/20 0.44
PSMD14 O00487 1/20 0.44
RECQL P46063 1/20 0.44
RXFP1 Q9HBX9 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
HCAR3 P49019 1/20 0.43
HCAR2 Q8TDS4 1/20 0.43
ALDH1A1 P00352 2/20 0.42
HPGD P15428 2/20 0.42
GAA P10253 1/20 0.42
HSD17B10 Q99714 1/20 0.42
APEX1 P27695 2/20 0.42
MTNR1B P49286 1/20 0.41
THRB P10828 1/20 0.41
TP53 P04637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10988273 0.94 HRH3 (0.51) HRH3RARBHCAR2ALDH1A1TP53
SCHEMBL10979939 0.94 HRH3 (0.51) HRH3RARBHCAR2ALDH1A1TP53
SCHEMBL10988758 0.94 HRH3 (0.51) HRH3RARBHCAR2ALDH1A1TP53
SCHEMBL10989313 0.94 HRH3 (0.51) HRH3RARBHCAR2ALDH1A1TP53
SCHEMBL10985371 0.94 HRH3 (0.51) HRH3RARBHCAR2ALDH1A1TP53
SCHEMBL10981244 0.94 HRH3 (0.51) HRH3RARBHCAR2ALDH1A1TP53
SCHEMBL6948860 0.94 HRH3 (0.51) HRH3RARBHCAR2ALDH1A1TP53
SCHEMBL10985255 0.94 HRH3 (0.51) HRH3RARBHCAR2ALDH1A1TP53
SCHEMBL10980000 0.94 HRH3 (0.51) HRH3RARBHCAR2ALDH1A1TP53
SCHEMBL10982578 0.94 HRH3 (0.51) HRH3RARBHCAR2ALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1590324-A1 NOVEL HETEROARYL-SUBSTITUTED ACETONE DERIVATIVES AS INHIBITORS OF PHOSPHOLIPASE A sb 2 /sb MERCKLE GMBH (DE) 2005-11-02 EP disclosed
WO-2004069797-A1 NOVEL HETEROARYL-SUBSTITUTED ACETONE DERIVATIVES AS INHIBITORS OF PHOSPHOLIPASE A2 MERCKLE GMBH (DE) 2004-08-19 WO disclosed