Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | APOB | P04114 | 1/20 | 0.39 |
| ▸ | MTTP | P55157 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5136027 | 1.00 | MEN1 (0.51) | MEN1KMT2AALDH1A1TACR1SLC6A2 | |
| SCHEMBL5359589 | 0.90 | MEN1 (0.51) | MEN1KMT2AALDH1A1TACR1SLC6A2 | |
| SCHEMBL5135771 | 0.90 | MEN1 (0.51) | MEN1KMT2AALDH1A1TACR1SLC6A2 | |
| SCHEMBL5137467 | 0.89 | KMT2A (0.48) | MEN1KMT2AALDH1A1TACR1SLC6A2 | |
| SCHEMBL5357497 | 0.89 | MEN1 (0.44) | MEN1KMT2AALDH1A1TACR1SLC6A2 | |
| SCHEMBL5137387 | 0.89 | MEN1 (0.57) | MEN1KMT2AALDH1A1TACR1SLC6A2 | |
| SCHEMBL5373300 | 0.86 | MEN1 (0.46) | MEN1KMT2AALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL5370790 | 0.86 | KMT2A (0.48) | MEN1KMT2AALDH1A1TACR1SLC6A2 | |
| SCHEMBL5358837 | 0.86 | LPAR1 (0.43) | MEN1KMT2AALDH1A1TACR1SLC6A2 | |
| SCHEMBL5135446 | 0.82 | AGER (0.43) | MEN1KMT2AALDH1A1KCNH2LTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487796-A4 | SUBSTITUTED BIARYL AMIDES AS C5A RECEPTOR MODULATORS | NEUROGEN CORP (US) | 2005-11-16 | — | — | EP | claimed |
| EP-1487796-A1 | SUBSTITUTED BIARYL AMIDES AS C5A RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2004-12-22 | — | — | EP | claimed |
| WO-2003082826-A1 | SUBSTITUTED BIARYL AMIDES AS C5A RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2003-10-09 | — | — | WO | claimed |