Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | JUN | P05412 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5988416 | 1.00 | CHRNA7 (0.52) | CHRNA7CHRNB2CHRNA4NAMPTNPC1 | |
| SCHEMBL6152579 | 1.00 | CHRNA7 (0.52) | CHRNA7CHRNB2CHRNA4NAMPTNPC1 | |
| SCHEMBL5988419 | 1.00 | CHRNA7 (0.52) | CHRNA7CHRNB2CHRNA4NAMPTNPC1 | |
| SCHEMBL5988374 | 0.85 | CHRM3 (0.47) | CHRNA7JUNNFKB1HTR3ACHRM2 | |
| SCHEMBL5988372 | 0.85 | CHRM3 (0.47) | CHRNA7JUNNFKB1HTR3ACHRM2 | |
| SCHEMBL6152857 | 0.85 | CHRM3 (0.47) | CHRNA7JUNNFKB1HTR3ACHRM2 | |
| SCHEMBL6152859 | 0.85 | CHRM3 (0.47) | CHRNA7JUNNFKB1HTR3ACHRM2 | |
| SCHEMBL374845 | 0.85 | CHRNA7 (0.59) | CHRNA7HTR3ACHRM2CHRM1CHRM3 | |
| SCHEMBL6153668 | 0.85 | CHRNA7 (0.59) | CHRNA7HTR3ACHRM2CHRM1CHRM3 | |
| SCHEMBL6153288 | 0.85 | CHRNA7 (0.59) | CHRNA7HTR3ACHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1233964-B1 | NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-22 | — | — | EP | claimed |
| US-6683090-B1 | N-(1-AZABICYCLO(2.2.2)OCT-3-YL)PROPENAMIDE DERIVATIVES; PSYCHOTIC AND INTELLECTUAL IMPAIRMENT DISORDERS | ASTRAZENECA AB (SE) | 2004-01-27 | — | — | US | claimed |
| EP-1233964-B1 | NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-22 | — | — | EP | disclosed |
| US-6683090-B1 | N-(1-AZABICYCLO(2.2.2)OCT-3-YL)PROPENAMIDE DERIVATIVES; PSYCHOTIC AND INTELLECTUAL IMPAIRMENT DISORDERS | ASTRAZENECA AB (SE) | 2004-01-27 | — | — | US | disclosed |