Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.59 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.59 |
| ▸ | HCK | P08631 | 11/20 | 0.59 |
| ▸ | TNF | P01375 | 3/20 | 0.59 |
| ▸ | CIT | O14578 | 1/20 | 0.44 |
| ▸ | MUSK | O15146 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844842 | 0.96 | MAPK14 (0.64) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL6574351 | 0.86 | MAPK14 (0.52) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL7854965 | 0.85 | MAPK14 (0.47) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL6244940 | 0.84 | MAPK14 (0.51) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL6575226 | 0.83 | MAPK14 (0.54) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL6165706 | 0.83 | MAPK14 (0.71) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL7854775 | 0.83 | MAPK14 (0.60) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL6578339 | 0.83 | MAPK14 (0.56) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL6572608 | 0.83 | GAA (0.45) | MAPK14MAPK12HCKTNFMAPK13 | |
| SCHEMBL7848428 | 0.82 | MAPK14 (0.52) | MAPK14MAPK12HCKTNFCIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534282-A2 | PHARMACEUTICAL COMPOSITIONS OF ANTICHOLINERGICS AND P38 KINASE INHIBITORS IN THE TREATMENT OF RESPIRATORY DISEASES | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004004725-A2 | PHARMACEUTICAL COMPOSITIONS OF ANTICHOLINERGICS AND P38 KINASE INHIBITORS IN THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-01-15 | — | — | WO | disclosed |