Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.41 |
| ▸ | HCK | P08631 | 2/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7854388 | 0.91 | CSF1R (0.42) | MAPK14MAPK12BRAFMEN1KMT2A | |
| SCHEMBL7854965 | 0.88 | MAPK14 (0.47) | MAPK14MAPK12HCKTNFCCR8 | |
| SCHEMBL7844842 | 0.83 | MAPK14 (0.64) | MAPK14MAPK12HCKTNFBRAF | |
| SCHEMBL6152746 | 0.83 | MAPK14 (0.59) | MAPK14MAPK12HCKTNFBRAF | |
| SCHEMBL6573925 | 0.80 | MAPK14 (0.51) | GAAMAPK14MAPK12HCKTNF | |
| SCHEMBL6263852 | 0.79 | ABL1 (0.51) | MAPK14MAPK12HCKTNFBRAF | |
| SCHEMBL7859356 | 0.77 | MAPK14 (0.39) | MAPK14MAPK12HCKTNFBRAF | |
| SCHEMBL7855117 | 0.77 | MAPK14 (0.38) | MAPK14MAPK12HCKTNF | |
| SCHEMBL7855430 | 0.77 | MAPK14 (0.54) | MAPK14MAPK12HCKTNFBRAF | |
| SCHEMBL6575226 | 0.77 | MAPK14 (0.54) | MAPK14MAPK12HCKTNFBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408950-A2 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003005999-A2 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-01-23 | — | — | WO | disclosed |
| EP-1147104-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000043384-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-07-27 | — | — | WO | disclosed |