Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 3/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL8848579 | 0.97 | CA1 (0.50) | CA1ALDH1A1SMN1; SMN2GAACA4 | |
| Tetrahydrofuran SCHEMBL28284327 | 0.94 | CA1 (0.47) | CA1ALDH1A1SMN1; SMN2GAACA4 | |
| Tetrahydrofuran SCHEMBL28192752 | 0.94 | CA1 (0.47) | CA1ALDH1A1SMN1; SMN2GAACA4 | |
| Tetrahydrofuran SCHEMBL7175969 | 0.94 | CA1 (0.47) | CA1ALDH1A1SMN1; SMN2GAACA4 | |
| Tetrahydrofuran SCHEMBL28668349 | 0.92 | CA1 (0.45) | CA1ALDH1A1SMN1; SMN2GAACA4 | |
| Tetrahydrofuran SCHEMBL28186348 | 0.92 | CA1 (0.44) | CA1ALDH1A1SMN1; SMN2GAACA4 | |
| Tetrahydrofuran SCHEMBL28302889 | 0.90 | CA1 (0.43) | CA1ALDH1A1SMN1; SMN2GAACA4 | |
| Tetrahydrofuran SCHEMBL11041905 | 0.88 | CA1 (0.41) | CA1ALDH1A1SMN1; SMN2GAACA4 | |
| Dioxane SCHEMBL13835212 | 0.88 | CA1 (0.60) | CA1SMN1; SMN2GAACA4CA12 | |
| Tetrahydrofuran SCHEMBL11210402 | 0.88 | ALDH1A1 (0.53) | CA1ALDH1A1SMN1; SMN2GAACA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114450001-A | 18 beta-glycyrrhetinic acid nano emulsion | 亚索事务公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-107466290-A | Substituted cyclic amides as herbicide | 杜邦公司 | 2017-12-12 | — | — | CN | disclosed |
| CN-106053678-A | Detection method for content of 4-hydroxyisoleucine in auxiliary hypoglycemic tablet deep processed product | 汤臣倍健股份有限公司 | 2016-10-26 | — | — | CN | disclosed |
| CN-102485727-B | Cefcapene pivoxil hydrochloride and method for preparing its intermediate | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY SHIJIAZHUANG CO LTD | 2014-05-07 | — | — | CN | disclosed |
| CN-102485727-A | Cefcapene pivoxil hydrochloride and method for preparing its intermediate | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY SHIJIAZHUANG CO LTD | 2012-06-06 | — | — | CN | disclosed |
| EP-1320372-B1 | USE OF SULFATIDES FOR TREATING DIABETES | BUSCHARD KARSTEN (DK) | 2005-11-23 | — | — | EP | disclosed |
| US-6908904-B2 | Pharmaceutical preparation and method for treatment of diabetes | BUSCHARD, KARSTEN (DK) | 2005-06-21 | — | — | US | disclosed |
| EP-1320372-A1 | PHARMACEUTICAL PREPARATION AND METHOD FOR TREATMENT OF DIABETES | A+Science AB (publ) (SE) | 2003-06-25 | — | — | EP | disclosed |
| US-20030004115-A1 | Pharmaceutical preparation and method for treatment of diabetes | FREDMAN, PAM (SE) | 2003-01-02 | — | — | US | disclosed |
| EP-0698114-B1 | METHOD FOR THE SYNTHESIS OF AMINO-DEOXY-DISACCHARIDES AND AMINO-DEOXY-OLIGOSACCHARIDES | BIOFLEXIN AB (SE) | 2002-12-04 | — | — | EP | disclosed |
| US-5856143-A | N-containing saccharides and method for the synthesis of N-containing saccharides from amino-deoxy-disaccharides and amino-deoxy-oligosaccharides | BIOFLEXIN AB (SE) | 1999-01-05 | — | — | US | disclosed |
| US-5532147-A | Enzymatic method for synthesis of carbohydrates | GLYCOREX TRANSPLANTATION AB (PUBL) (SE) | 1996-07-02 | — | — | US | disclosed |
| EP-0698114-A1 | METHOD FOR THE SYNTHESIS OF AMINO-DEOXY-DISACCHARIDES AND AMINO-DEOXY-OLIGOSACCHARIDES | BIOFLEXIN AB (SE) | 1996-02-28 | — | — | EP | disclosed |
| WO-1994029477-A1 | METHOD FOR THE SYNTHESIS OF AMINO-DEOXY-DISACCHARIDES AND AMINO-DEOXY-OLIGOSACCHARIDES | PROCUR AB (SE) | 1994-12-22 | — | — | WO | disclosed |
| EP-0598051-A1 | ENZYMATIC METHOD FOR SYNTHESIS OF CARBOHYDRATES | BIOFLEXIN AB (SE) | 1994-05-25 | — | — | EP | disclosed |
| WO-1993003168-A1 | ENZYMATIC METHOD FOR SYNTHESIS OF CARBOHYDRATES | NILSSON KURT (SE) | 1993-02-18 | — | — | WO | disclosed |
| US-4680390-A | CEPHALOSPORINS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-07-14 | — | — | US | disclosed |
| US-4520194-A | BACTERICIDES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1985-05-28 | — | — | US | disclosed |
| US-4510138-A | 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]cephalosporin derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1985-04-09 | — | — | US | disclosed |
| US-4278671-A | ANTIBIOTICS, BACTERICIDES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-07-14 | — | — | US | disclosed |