Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Di(Hydroxyethyl)Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Di(Hydroxyethyl)Ether SCHEMBL11145760 | 0.97 | TSHR (0.67) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Triethylene Glycol SCHEMBL15413179 | 0.94 | MEN1 (0.69) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Piperazine SCHEMBL28021030 | 0.85 | ALDH1A1 (0.64) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL28251840 | 0.82 | MEN1 (0.50) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL6843563 | 0.82 | MEN1 (0.50) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Triethylene Glycol SCHEMBL17394669 | 0.79 | MEN1 (0.92) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL1462 | 0.79 | — | — | |
| Di(Hydroxyethyl)Ether SCHEMBL2410410 | 0.79 | TSHR (1.00) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL7805707 | 0.76 | TSHR (0.77) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL19305255 | 0.75 | MEN1 (1.00) | TSHRMAPK1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115337296-B | Composite material for inhibiting drug-resistant plasmid horizontal transfer and preparation method and application thereof | 华南农业大学 | 2024-01-19 | — | — | CN | claimed |
| CN-107663183-A | A kind of preparation method of piperazine diethylene glycol (DEG) | 江西佰利达制药有限公司 | 2018-02-06 | — | — | CN | claimed |
| CN-107663183-A | A kind of preparation method of piperazine diethylene glycol (DEG) | 江西佰利达制药有限公司 | 2018-02-06 | — | — | CN | disclosed |
| CN-107663183-A | A kind of preparation method of piperazine diethylene glycol (DEG) | 江西佰利达制药有限公司 | 2018-02-06 | — | — | CN | disclosed |
| CN-107663183-A | A kind of preparation method of piperazine diethylene glycol (DEG) | 江西佰利达制药有限公司 | 2018-02-06 | — | — | CN | disclosed |
| EP-1038669-B1 | Method of producing directly imageable waterless planographic printing plate | TORAY INDUSTRIES (JP) | 2005-01-26 | — | — | EP | disclosed |
| US-6284433-B1 | IMAGEWISELY IRRADIATING PRECURSOR OF PRINTING PLATE WITH LASER BEAM, PRE-TREATING PRECURSOR WITH GLYCOL COMPOUND AND/OR A GLYCOL ETHER COMPOUND; REMOVING INK REPELLENT LAYER WHEREIN HEAT SENSITIVE LAYER IS PARTIALLY LEFT ON PRINTING PLATE | TORAY INDUSTRIES, INC. (JP) | 2001-09-04 | — | — | US | disclosed |
| EP-1038669-A1 | Method of producing directly imageable waterless planographic printing plate | TORAY INDUSTRIES, INC. (JP) | 2000-09-27 | — | — | EP | disclosed |