Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.55 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.50 |
| ▸ | HTR3B | O95264 | 3/20 | 0.50 |
| ▸ | HTR3A | P46098 | 3/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152696 | 1.00 | CHRNA7 (0.59) | CHRNA7CHRM2CHRM1CHRM3HTR3E | |
| SCHEMBL6153443 | 1.00 | CHRNA7 (0.59) | CHRNA7CHRM2CHRM1CHRM3HTR3E | |
| SCHEMBL7059619 | 0.76 | CHRNA7 (0.53) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL3225472 | 0.76 | CHRNA7 (0.78) | CHRNA7CHRM2CHRM1CHRM3HTR3E | |
| SCHEMBL2218010 | 0.76 | CHRNA7 (0.78) | CHRNA7CHRM2CHRM1CHRM3HTR3E | |
| SCHEMBL3216388 | 0.76 | CHRNA7 (0.78) | CHRNA7CHRM2CHRM1CHRM3HTR3E | |
| Hydrochloric Acid SCHEMBL7278119 | 0.74 | CHRNA7 (0.76) | CHRNA7CHRM2CHRM1CHRM3HTR3E | |
| Hydrochloric Acid SCHEMBL18704540 | 0.74 | CHRNA7 (0.76) | CHRNA7CHRM2CHRM1CHRM3HTR3E | |
| SCHEMBL3320988 | 0.74 | CHRNA7 (0.58) | CHRNA7CHRM2CHRM1CHRM3HTR3E | |
| SCHEMBL3319640 | 0.74 | CHRNA7 (0.58) | CHRNA7CHRM2CHRM1CHRM3HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1233964-B1 | NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-22 | — | — | EP | claimed |
| JP-2003514818-A | — | — | 2003-04-22 | — | — | JP | claimed |
| EP-1233964-A1 | NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2002-08-28 | — | — | EP | claimed |
| WO-2001036417-A1 | NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-05-25 | — | — | WO | claimed |
| EP-1233964-B1 | NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-22 | — | — | EP | disclosed |
| US-6683090-B1 | N-(1-AZABICYCLO(2.2.2)OCT-3-YL)PROPENAMIDE DERIVATIVES; PSYCHOTIC AND INTELLECTUAL IMPAIRMENT DISORDERS | ASTRAZENECA AB (SE) | 2004-01-27 | — | — | US | disclosed |