SCHEMBL3319640

SCHEMBL3319640

O=C(O)NC1CN2CCC1CC2

nearest known ligand 0.60

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 5/20 0.58
CA12 O43570 3/20 0.56
CA1 P00915 3/20 0.56
CA2 P00918 3/20 0.56
CA9 Q16790 3/20 0.56
CHRM2 P08172 1/20 0.54
CHRM1 P11229 1/20 0.54
CHRM3 P20309 1/20 0.54
HTR3E A5X5Y0 1/20 0.53
HTR3B O95264 1/20 0.53
ALOX15 P16050 1/20 0.53
TSHR P16473 1/20 0.53
HTR3A P46098 1/20 0.53
HTR3D Q70Z44 1/20 0.53
HTR3C Q8WXA8 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3319631 1.00 CHRNA7 (0.58) CHRNA7CA12CA1CA2CA9
SCHEMBL3320988 1.00 CHRNA7 (0.58) CHRNA7CA12CA1CA2CA9
SCHEMBL8050322 0.82 CA12 (0.55) CHRNA7CA12CA1CA2CA9
SCHEMBL14514757 0.82 CA12 (0.55) CHRNA7CA12CA1CA2CA9
SCHEMBL13525452 0.82 CA12 (0.55) CHRNA7CA12CA1CA2CA9
SCHEMBL16790664 0.82 CA12 (0.55) CHRNA7CA12CA1CA2CA9
SCHEMBL5892019 0.82 CA12 (0.55) CHRNA7CA12CA1CA2CA9
SCHEMBL6683718 0.82 CA12 (0.55) CHRNA7CA12CA1CA2CA9
SCHEMBL9303682 0.82 CA12 (0.55) CHRNA7CA12CA1CA2CA9
SCHEMBL879026 0.82 CA12 (0.55) CHRNA7CA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170273957-A1 ANTITUSSIVE COMPOSITIONS AND METHODS ATTENUA, INC. 2017-09-28 US claimed
EP-2959902-A1 USE OF AZABICYCLOALKYL DERIVATIVES FOR THE TREATMENT OR PREVENTION OF ATAXIA Novartis AG (CH) 2015-12-30 EP claimed
US-20130225560-A1 Treatment of Cognitive Disorders with Certain Alpha-7 Nicotinic Acid Receptor Agonists in Combination with Acetylcholinesterase Inhibitors ENVIVO PHARMACEUTICALS, INC. (US) 2013-08-29 US claimed
EP-2598135-A1 TREATMENT OF COGNITIVE DISORDERS WITH CERTAIN ALPHA-7 NICOTINIC ACID RECEPTOR AGONISTS IN COMBINATION WITH ACETYLCHOLINESTERASE INHIBITORS Koenig, Gerhard (US) 2013-06-05 EP claimed
WO-2012015749-A1 TREATMENT OF COGNITIVE DISORDERS WITH CERTAIN ALPHA-7 NICOTINIC ACID RECEPTOR AGONISTS IN COMBINATION WITH ACETYLCHOLINESTERASE INHIBITORS ENVIVO PHARMACEUTICALS, INC. (US) 2012-02-02 WO claimed
CN-117679415-A Glucoamide synthase inhibitors 建新公司 2024-03-12 CN disclosed
US-20220211679-A1 ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS NOVARTIS AG (CH) 2022-07-07 US disclosed
US-11359241-B2 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment NOVARTIS AG (CH) 2022-06-14 US disclosed
US-11311525-B2 Use of alpha 7 nicotinic acetylcholine receptor agonists NOVARTIS AG (CH) 2022-04-26 US disclosed
US-20210338621-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG (CH) 2021-11-04 US disclosed
EP-2945633-B1 USE OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS NOVARTIS AG (CH) 2021-06-30 EP disclosed
EP-2945637-B1 USE OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS NOVARTIS AG (CH) 2021-03-10 EP disclosed
US-20120172346-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG 2012-07-05 US disclosed
US-20120157464-A1 USE OF AZABICYCLOALKYL DERIVATIVES OR PYRROLIDINE-2-ONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF ATAXIA NOVARTIS AG 2012-06-21 US disclosed
WO-2012015749-A1 TREATMENT OF COGNITIVE DISORDERS WITH CERTAIN ALPHA-7 NICOTINIC ACID RECEPTOR AGONISTS IN COMBINATION WITH ACETYLCHOLINESTERASE INHIBITORS ENVIVO PHARMACEUTICALS, INC. (US) 2012-02-02 WO disclosed
US-20100125063-A1 COMBINATIONS OF NICOTINIC ACETYLCHOLINE ALPHA 7 RECEPTOR AGONISTS NOVARTIS AG 2010-05-20 US disclosed
EP-2135609-A1 Combinations of nicotinic acetylcholine alpha 7 receptor agonists Novartis AG (CH) 2009-12-23 EP disclosed
US-20080306081-A1 Combinations of Nicotinic Acetylcholine Alpha 7 Receptor Antagonists NOVARTIS AG (CH) 2008-12-11 US disclosed
EP-1809285-A1 COMBINATIONS OF NICOTINIC ACETYLCHOLINE ALPHA 7 RECEPTOR AGONISTS Novartis AG (CH) 2007-07-25 EP disclosed
WO-2006048294-A1 COMBINATIONS OF NICOTINIC ACETYLCHOLINE ALPHA 7 RECEPTOR AGONISTS NOVARTIS AG (CH) 2006-05-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11311525-B2 Use of alpha 7 nicotinic acetylcholine receptor agonists CHRNA7, CHRNA1, CHRNA5 CHRNA7 1/4885CA12 2331/4885CA1 1049/4885
US-20170273957-A1 ANTITUSSIVE COMPOSITIONS AND METHODS CHRNA7, CHRNA1, CHRNG CHRNA7 1/4885CA12 1246/4885CA1 777/4885
US-20120172346-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS CHRNA7, CHRNA5, CHRNA4 CHRNA7 1/4885CA12 4389/4885CA1 3269/4885
US-20100125063-A1 COMBINATIONS OF NICOTINIC ACETYLCHOLINE ALPHA 7 RECEPTOR AGONISTS CHRNA7, CHRNA4, CHRNA10 CHRNA7 1/4885CA12 4409/4885CA1 2276/4885
US-20130225560-A1 Treatment of Cognitive Disorders with Certain Alpha-7 Nicotinic Acid Receptor Agonists in Combination with Acetylcholinesterase Inhibitors CHRNA7, CHRNA6, CHRNA2 CHRNA7 1/4885CA12 1795/4885CA1 593/4885
US-20220211679-A1 ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS CHRNA7, CHRNA1, CHRNA4 CHRNA7 1/4885CA12 3676/4885CA1 2119/4885
US-20080306081-A1 Combinations of Nicotinic Acetylcholine Alpha 7 Receptor Antagonists CHRNA7, CHRNA4, CHRNA10 CHRNA7 1/4885CA12 4333/4885CA1 1999/4885
US-20120157464-A1 USE OF AZABICYCLOALKYL DERIVATIVES OR PYRROLIDINE-2-ONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF ATAXIA ATXN2, CDR2, ATXN2L CHRNA7 205/4885CA12 3729/4885CA1 1765/4885
US-11359241-B2 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment CHRNA7, CHRNA4, CHRNA5 CHRNA7 1/4885CA12 2347/4885CA1 1331/4885
US-20210338621-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS CHRNA7, CHRNA5, CHRNA4 CHRNA7 1/4885CA12 4389/4885CA1 3269/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.