Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TYMP | P19971 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | TK1 | P04183 | 2/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26447806 | 0.81 | MAPK1 (0.40) | MAPK1SMN1; SMN2HPGDTYMPALDH1A1 | |
| SCHEMBL784395 | 0.81 | MAPK1 (0.43) | MAPK1SMN1; SMN2HPGDTYMPALDH1A1 | |
| SCHEMBL17899459 | 0.81 | SMN1; SMN2 (0.62) | SMN1; SMN2HPGDLMNAPOLBMET | |
| SCHEMBL12646693 | 0.80 | SMN1; SMN2 (0.40) | MAPK1SMN1; SMN2HPGDTYMPALDH1A1 | |
| SCHEMBL14537782 | 0.80 | SMN1; SMN2 (0.40) | MAPK1SMN1; SMN2HPGDTYMPALDH1A1 | |
| SCHEMBL12016833 | 0.80 | SMN1; SMN2 (0.40) | MAPK1SMN1; SMN2HPGDTYMPALDH1A1 | |
| SCHEMBL6998418 | 0.78 | MAPK1 (0.43) | MAPK1SMN1; SMN2HPGDTYMPALDH1A1 | |
| SCHEMBL4194708 | 0.78 | MAPK1 (0.41) | MAPK1HPGDTYMPALDH1A1LMNA | |
| SCHEMBL22759941 | 0.78 | MAPK1 (0.41) | MAPK1SMN1; SMN2HPGDTYMPALDH1A1 | |
| SCHEMBL9155069 | 0.78 | TYMP (0.43) | MAPK1HPGDTYMPALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024137663-A2 | TREATMENT OF DKK2 RELATED DISEASES AND DISORDERS | EMPIRICO INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-2023245118-A2 | TREATMENT OF MS4A4E RELATED DISEASES AND DISORDERS | EMPIRICO INC. (US) | 2023-12-21 | — | — | WO | disclosed |
| EP-1499627-A2 | NUCLEASE RESISTANT CHIMERIC OLIGONUCLEOTIDES | ISIS Pharmaceuticals, Inc. (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003004602-A2 | NUCLEASE RESISTANT CHIMERIC OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 2003-01-16 | — | — | WO | disclosed |