Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 14/20 | 0.63 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.53 |
| ▸ | TMIGD3 | P0DMS9 | 3/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1001748 | 0.87 | TLR7 (0.64) | TLR7ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL5732120 | 0.86 | TLR7 (0.63) | TLR7ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL7210343 | 0.82 | TLR7 (0.70) | TLR7 | |
| SCHEMBL7209457 | 0.81 | ADORA2A (0.72) | TLR7ADORA2AADORA1ADORA2BTMIGD3 | |
| SCHEMBL7206709 | 0.81 | ADORA2A (0.53) | TLR7ADORA2AADORA1ADORA2BTMIGD3 | |
| SCHEMBL7204011 | 0.81 | TLR7 (0.74) | TLR7 | |
| SCHEMBL5731164 | 0.80 | TLR7 (0.55) | TLR7ADORA2AADORA1ADORA2B | |
| SCHEMBL7205585 | 0.80 | ADORA2A (0.54) | TLR7ADORA2AADORA1ADORA2BTMIGD3 | |
| SCHEMBL7209091 | 0.80 | ADORA2A (0.74) | TLR7ADORA2AADORA1ADORA2BTMIGD3 | |
| SCHEMBL1146042 | 0.79 | TLR7 (0.43) | TLR7ADORA2AADORA1ADORA2BTMIGD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882727-B9 | NOVEL PURINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2005-06-15 | — | — | EP | disclosed |
| EP-0882727-B1 | NOVEL PURINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2004-12-01 | — | — | EP | disclosed |
| US-6028076-A | FOR INDUCING .ALPHA.-INTERFERON IN A PATIENT HAVING HEPATITIS B OR C, BY ADMINISTERING PURINE DERIVATIVE | JAPAN ENERGY CORPORATION (JP) | 2000-02-22 | — | — | US | disclosed |
| EP-0882727-A1 | NOVEL PURINE DERIVATIVES | JAPAN ENERGY CORPORATION (JP) | 1998-12-09 | — | — | EP | disclosed |