SCHEMBL1001748

SCHEMBL1001748

CCCCCc1nc(N)c2nc(O)n(Cc3ccccc3)c2n1

nearest known ligand 0.64

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 19/20 0.64
ADORA3 P0DMS8 1/20 0.47
ADORA2A P29274 1/20 0.47
ADORA2B P29275 1/20 0.47
ADORA1 P30542 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5732120 0.99 TLR7 (0.63) TLR7ADORA3ADORA2AADORA2BADORA1
SCHEMBL5731164 0.93 TLR7 (0.55) TLR7ADORA2AADORA2BADORA1
SCHEMBL10174942 0.88 TLR7 (0.49) TLR7ADORA2AADORA1
SCHEMBL6153574 0.87 TLR7 (0.63) TLR7ADORA3ADORA2AADORA2BADORA1
SCHEMBL14983804 0.85 TLR7 (0.48) TLR7ADORA2AADORA2BADORA1
SCHEMBL7209551 0.85 TLR7 (0.48) TLR7ADORA2AADORA2BADORA1
SCHEMBL5730393 0.85 TLR7 (0.55) TLR7ADORA3ADORA2AADORA2BADORA1
SCHEMBL23421512 0.84 TLR7 (0.48) TLR7ADORA3ADORA2AADORA2BADORA1
SCHEMBL27538541 0.84 TLR7 (0.53) TLR7
SCHEMBL5731379 0.84 TLR7 (0.45) TLR7ADORA2AADORA2BADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200390881-A1 NANOCARRIERS POSSESSING COMPONENTS WITH DIFFERENT RATES OF RELEASE SELECTA BIOSCIENCES, INC. (US) 2020-12-17 US disclosed
US-20180256709-A1 IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS SELECTA BIOSCIENCES, INC. (US) 2018-09-13 US disclosed
US-9884112-B2 Immunomodulatory agent-polymeric compounds SELECTA BIOSCIENCES, INC. (US) 2018-02-06 US disclosed
US-20150328300-A1 IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS SELECTA BIOSCIENCES, INC. (US) 2015-11-19 US disclosed
US-9006254-B2 Immunomodulatory agent-polymeric compounds SELECTA BIOSCIENCES, INC. (US) 2015-04-14 US disclosed
US-20140242173-A1 TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS SELECTA BIOSCIENCES, INC. (US) 2014-08-28 US disclosed
US-20140193453-A1 IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS SELECTA BIOSCIENCES, INC. (US) 2014-07-10 US disclosed
US-20140030344-A1 TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOSTIMULATORY AGENTS SELECTA BIOSCIENCES, INC. (US) 2014-01-30 US disclosed
EP-2435092-A2 NANOCARRIERS POSSESSING COMPONENTS WITH DIFFERENT RATES OF RELEASE Selecta Biosciences, Inc. (US) 2012-04-04 EP disclosed
EP-2435095-A2 IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS Selecta Biosciences, Inc. (US) 2012-04-04 EP disclosed
WO-2010138193-A2 TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS SELECTA BIOSCIENCES, INC. (US) 2010-12-02 WO disclosed
EP-1043021-B1 PURINE DERIVATIVES FOR THE TREATMENT OF ALLERGIC DISEASES AND SYSTEMIC LUPUS ERYTHEMATOSUS DAINIPPON SUMITOMO PHARMA CO (JP) 2006-05-03 EP disclosed
EP-1551832-A1 8-AZABICYCLO[3.2.1]OCTANE ETHER DERIVATIVES AND THEIR USE AS NEUROKININ RECEPTOR ANTAGONISTS MERCK SHARP & DOHME LTD. (GB) 2005-07-13 EP disclosed
EP-0882727-B9 NOVEL PURINE DERIVATIVES SUMITOMO PHARMA (JP) 2005-06-15 EP disclosed
EP-0882727-B1 NOVEL PURINE DERIVATIVES SUMITOMO PHARMA (JP) 2004-12-01 EP disclosed
WO-2004031185-A1 8-AZABICYCLO[3.2.1]OCTANE ETHER DERIVATIVES AND THEIR USE AS NEUROKININ RECEPTOR ANTAGONISTS MERCK SHARP & DOHME LIMITED (GB) 2004-04-15 WO disclosed
US-6376501-B1 INHIBITING OR REGULATING IMMUNE RESPONSE USING PURINE-DERIVED COMPOUND; NON-STEROIDAL COMPOUND JAPAN ENERGY CORPORATION (JP) 2002-04-23 US disclosed
EP-1043021-A1 TYPE 2 HELPER T CELL-SELECTIVE IMMUNE RESPONSE SUPPRESSORS Japan Energy Corporation (JP) 2000-10-11 EP disclosed
US-6028076-A FOR INDUCING .ALPHA.-INTERFERON IN A PATIENT HAVING HEPATITIS B OR C, BY ADMINISTERING PURINE DERIVATIVE JAPAN ENERGY CORPORATION (JP) 2000-02-22 US disclosed
EP-0882727-A1 NOVEL PURINE DERIVATIVES JAPAN ENERGY CORPORATION (JP) 1998-12-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150328300-A1 IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS CD47, TLR3, IL2 TLR7 41/4885ADORA3 3227/4885ADORA2A 1537/4885
US-20200390881-A1 NANOCARRIERS POSSESSING COMPONENTS WITH DIFFERENT RATES OF RELEASE CD47, MSR1, CD14 TLR7 118/4885ADORA3 2823/4885ADORA2A 1230/4885
US-20180256709-A1 IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS CD47, TLR3, IL2 TLR7 41/4885ADORA3 3227/4885ADORA2A 1537/4885
US-20140193453-A1 IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS CD47, TLR3, IL2 TLR7 41/4885ADORA3 3227/4885ADORA2A 1537/4885
US-20140030344-A1 TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOSTIMULATORY AGENTS CD47, IFNG, NFATC1 TLR7 39/4885ADORA3 3439/4885ADORA2A 2179/4885
US-20140242173-A1 TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS CD47, IFNG, TSLP TLR7 31/4885ADORA3 3217/4885ADORA2A 1851/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.