Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 6/20 | 0.43 |
| ▸ | RRM1 | P23921 | 3/20 | 0.43 |
| ▸ | RRM2 | P31350 | 3/20 | 0.43 |
| ▸ | RRM2B | Q7LG56 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154720 | 0.75 | IDO1 (0.44) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL6154206 | 0.74 | HDAC6 (0.40) | NPC1RAB9ASMN1; SMN2MAPK1MAPT | |
| SCHEMBL6154208 | 0.74 | HDAC6 (0.40) | NPC1RAB9ASMN1; SMN2MAPK1MAPT | |
| Ammonia Solution, Strong SCHEMBL6155214 | 0.73 | HDAC6 (0.40) | NPC1RAB9ASMN1; SMN2MAPK1MAPT | |
| Cinnamic Acid SCHEMBL29454354 | 0.60 | HDAC2 (0.76) | NPC1RAB9ASMN1; SMN2MAPK1HDAC8 | |
| SCHEMBL4955280 | 0.60 | DPP4 (0.44) | KMT2AALDH1A1MAOAMAOB | |
| SCHEMBL6153697 | 0.60 | CA12 (0.41) | NPC1RAB9ASMN1; SMN2GAAMAPT | |
| SCHEMBL6154721 | 0.60 | IDO1 (0.46) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL21882813 | 0.60 | HCAR2 (0.50) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL4959824 | 0.60 | MIF (0.41) | NPC1RAB9ASMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | PTPRS, PTPRJ, PTPRCAP | NPC1 4548/4885RAB9A 3814/4885SMN1; SMN2 2211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.