Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 8/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460238 | 0.81 | KMT2A (0.54) | OPRM1OPRD1OPRK1KCNH2MAPK1 | |
| SCHEMBL7226906 | 0.80 | GAA (0.50) | LTA4HOPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL7237208 | 0.80 | GAA (0.50) | LTA4HOPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL4396685 | 0.80 | GAA (0.50) | LTA4HOPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL3524222 | 0.80 | CHRM1 (0.55) | LTA4HALDH1A1MAPK1KMT2AHTT | |
| SCHEMBL7464902 | 0.77 | CHRM4 (0.54) | OPRM1OPRD1OPRK1KCNH2MEN1 | |
| SCHEMBL1574043 | 0.76 | MEN1 (0.55) | MEN1MAPK1KMT2AGAACHRM1 | |
| SCHEMBL21773167 | 0.76 | MEN1 (0.55) | MEN1MAPK1KMT2AGAACHRM1 | |
| SCHEMBL21773164 | 0.76 | MEN1 (0.55) | MEN1MAPK1KMT2AGAACHRM1 | |
| SCHEMBL21777609 | 0.76 | MEN1 (0.55) | MEN1MAPK1KMT2AGAACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569646-A2 | PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004054974-A2 | PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-07-01 | — | — | WO | disclosed |