Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.54 |
| ▸ | HRH1 | P35367 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.54 |
| ▸ | HTR3B | O95264 | 2/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.54 |
| ▸ | HTR3A | P46098 | 2/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.54 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.54 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13850002 | 0.93 | CHRM4 (0.59) | CHRM4CHRM5HRH1SIGMAR1HTR3E | |
| SCHEMBL2145704 | 0.93 | CHRNA3 (0.63) | CHRM4CHRM5HRH1SIGMAR1HTR3E | |
| SCHEMBL12925024 | 0.91 | CHRM4 (0.47) | CHRM4CHRM5HRH1SIGMAR1HTR3E | |
| SCHEMBL748392 | 0.80 | HTR3E (0.50) | CHRM4CHRM5HRH1SIGMAR1HTR3E | |
| SCHEMBL748393 | 0.80 | HTR3E (0.50) | CHRM4CHRM5HRH1SIGMAR1HTR3E | |
| SCHEMBL7457968 | 0.78 | LMNA (0.49) | HTR3ACHRM1SLC6A2SLC6A3CHRM3 | |
| SCHEMBL6153901 | 0.77 | LTA4H (0.49) | CHRM4CHRM5CHRM1OPRM1OPRD1 | |
| SCHEMBL6893103 | 0.77 | HTR3E (0.54) | CHRM4CHRM5HRH1SIGMAR1HTR3E | |
| SCHEMBL6886547 | 0.77 | HTR3E (0.54) | CHRM4CHRM5HRH1SIGMAR1HTR3E | |
| SCHEMBL14017444 | 0.76 | HTR3A (0.60) | CHRM4CHRM5HRH1SIGMAR1HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242421-A1 | 4-[ARYL(8-AZABICYCLO[3.2.1] OCTAN-3-YL)] AMINOBENZOIC ACID DERIVATIVES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2002-09-25 | — | — | EP | disclosed |
| US-6306876-B1 | DRUGS WITH DIASTERIOMERS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-10-23 | — | — | US | disclosed |
| WO-2001046191-A1 | 4-[ARYL(8-AZABICYCLO[3.2.1]OCTAN-3-YL)]AMINOBENZOIC ACID DERIVATIVES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-06-28 | — | — | WO | disclosed |