Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pramipexole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 0.60 |
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.60 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.60 |
| ▸ | HRH2 | P25021 | 2/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | HTR1B | P28222 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | HRH1 | P35367 | 1/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.60 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.46 |
| ▸ | SCN4A | P35499 | 3/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pramipexole SCHEMBL6150838 | 0.97 | DRD3 (0.61) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL6150982 | 0.97 | DRD3 (0.61) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL28865335 | 0.85 | DRD3 (0.73) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL4795641 | 0.85 | DRD3 (0.73) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL6154157 | 0.84 | DRD3 (0.57) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL4799289 | 0.84 | DRD3 (0.70) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL4801696 | 0.82 | DRD3 (0.85) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL4802595 | 0.82 | DRD3 (0.85) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL6150983 | 0.81 | DRD3 (0.58) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Pramipexole SCHEMBL4797279 | 0.81 | DRD3 (0.92) | DRD3DRD2HRH2ADRA2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318987-B1 | PROCESS FOR RESOLUTION OF 2-AMINO-6-PROPYLAMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLE AND COMPOUNDS THEREFOR | SYNTHON BV (NL) | 2005-08-10 | — | — | EP | claimed |