Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.54 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3078778 | 0.74 | ENPP2 (0.58) | ENPP2KCNJ1KCNH2GRIA3GRIA4 | |
| SCHEMBL2731118 | 0.67 | KCNJ1 (0.50) | ENPP2KCNJ1KCNH2GRIA3GRIA4 | |
| SCHEMBL11042759 | 0.66 | ENPP2 (0.48) | ENPP2HSD17B10ALDH1A1TSHRMAPK1 | |
| SCHEMBL1107280 | 0.65 | ENPP2 (0.48) | ENPP2KCNJ1KCNH2HSD17B10ALDH1A1 | |
| SCHEMBL12621103 | 0.65 | ENPP2 (0.54) | ENPP2KCNJ1KCNH2GRIA3GRIA4 | |
| SCHEMBL14666985 | 0.65 | KDM4E (0.48) | ENPP2KCNJ1KCNH2PKMEPAS1 | |
| SCHEMBL2056122 | 0.65 | KCNJ1 (0.53) | ENPP2KCNJ1KCNH2HSD17B10ALDH1A1 | |
| SCHEMBL439914 | 0.65 | ENPP2 (1.00) | ENPP2KCNJ1KCNH2GRIA3GRIA4 | |
| SCHEMBL19335633 | 0.64 | ENPP2 (0.47) | ENPP2KCNJ1KCNH2GRIA3GRIA4 | |
| SCHEMBL14081326 | 0.64 | ENPP2 (0.52) | ENPP2KCNJ1KCNH2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | PTPRS, PTPRJ, PTPRCAP | ENPP2 269/4885KCNJ1 4290/4885KCNH2 4269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.