Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.41 |
| ▸ | VDR | P11473 | 8/20 | 0.35 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 3/20 | 0.32 |
| ▸ | PPARA | Q07869 | 3/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6155238 | 1.00 | HMGCR (0.41) | HMGCRVDRCYP24A1HSP90AA1HSP90AB1 | |
| SCHEMBL6155797 | 0.82 | HMGCR (0.49) | HMGCRVDRCYP24A1HSP90AA1HSP90AB1 | |
| SCHEMBL6155792 | 0.82 | HMGCR (0.49) | HMGCRVDRCYP24A1HSP90AA1HSP90AB1 | |
| SCHEMBL6879672 | 0.82 | HMGCR (0.33) | HMGCR | |
| SCHEMBL2106083 | 0.81 | PTGS1 (0.50) | HMGCRVDRCYP24A1PTGS1 | |
| SCHEMBL6155325 | 0.81 | PTGS1 (0.50) | HMGCRVDRCYP24A1PTGS1 | |
| SCHEMBL30534402 | 0.76 | HMGCR (0.48) | HMGCRVDRCYP24A1 | |
| SCHEMBL6156155 | 0.72 | HMGCR (0.49) | HMGCRVDRCYP24A1HSP90AA1HSP90AB1 | |
| SCHEMBL2106283 | 0.70 | HMGCR (0.57) | HMGCR | |
| SCHEMBL2108149 | 0.70 | HMGCR (0.57) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124779-B1 | VITAMIN D ANALOGUES | GALDERMA RES & DEV (FR) | 2005-02-02 | — | — | EP | disclosed |
| US-6689922-B1 | BIAROMATIC COMPOUNDS WHICH ARE ANALOGUES OF VITAMIN D HAVE A MARKED ACTIVITY IN THE FIELDS OF CELL DIFFERENTIATION AND PROLIFERATION | GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) | 2004-02-10 | — | — | US | disclosed |
| EP-1124779-A1 | VITAMIN D ANALOGUES | Galderma Research & Development, S.N.C. (FR) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026167-A1 | VITAMIN D ANALOGUES | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2000-05-11 | — | — | WO | disclosed |