Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | BDKRB2 | P30411 | 7/20 | 0.34 |
| ▸ | TACR1 | P25103 | 4/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154977 | 0.86 | SCN2A (0.51) | SIGMAR1MEN1KMT2ASMN1; SMN2EPHX1 | |
| SCHEMBL6156082 | 0.82 | SCN2A (0.44) | SIGMAR1KDM4EALDH1A1SCN2A | |
| SCHEMBL6154972 | 0.81 | EPHX1 (0.36) | SIGMAR1MEN1KMT2ASMN1; SMN2EPHX1 | |
| SCHEMBL6155071 | 0.76 | SCN2A (0.60) | MEN1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6157311 | 0.74 | SIGMAR1 (0.36) | SIGMAR1KMT2ASCN2A | |
| SCHEMBL6155032 | 0.67 | SCN2A (0.64) | SIGMAR1MEN1KMT2ASCN2A | |
| SCHEMBL6155365 | 0.67 | SIGMAR1 (0.76) | SIGMAR1SMN1; SMN2EPHX1KDM4EALDH1A1 | |
| SCHEMBL6155066 | 0.65 | SCN2A (0.45) | SIGMAR1KDM4EALDH1A1SCN2A | |
| SCHEMBL2740863 | 0.63 | EPHX1 (0.52) | SIGMAR1MEN1KMT2ASMN1; SMN2EPHX1 | |
| SCHEMBL10493615 | 0.63 | EPHX1 (0.63) | MEN1KMT2ASMN1; SMN2EPHX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0940139-B1 | Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers | SCION PHARMACEUTICALS INC (US) | 2005-02-02 | — | — | EP | claimed |
| EP-0940139-A2 | Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers | CAMBRIDGE NEUROSCIENCE RESEARCH, INC. (US) | 1999-09-08 | — | — | EP | claimed |
| US-5403861-A | Treating or preventing nerve cell death | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1995-04-04 | — | — | US | claimed |
| WO-1999002145-A1 | COMBINATION DRUG THERAPIES COMPRISING AMINOGLYCOSIDE ANTIBIOTICS AND N,N'-DISUBSTITUTED GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-01-21 | — | — | WO | disclosed |