Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.57 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.42 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6155315 | 1.00 | SYK (0.57) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL6155026 | 0.84 | SYK (0.64) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL6155035 | 0.84 | SYK (0.64) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL6155954 | 0.80 | SYK (0.50) | SYKAURKB | |
| SCHEMBL6155956 | 0.80 | SYK (0.50) | SYKAURKB | |
| SCHEMBL23397913 | 0.76 | SYK (0.53) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL1986849 | 0.76 | SYK (0.53) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL6155667 | 0.75 | SYK (0.70) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL6155657 | 0.75 | SYK (0.70) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL15631805 | 0.75 | SYK (0.77) | SYKMAPK3MAPK1KCNH2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1184376-B1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-02-02 | — | — | EP | disclosed |
| US-6797706-B1 | Heterocyclecarboxamide derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2004-09-28 | — | — | US | disclosed |
| EP-1184376-A1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-03-06 | — | — | EP | disclosed |