Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.50 |
| ▸ | FER | P16591 | 4/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6155956 | 1.00 | SYK (0.50) | SYKFERPRKCQEGFRRAF1 | |
| SCHEMBL6155738 | 0.91 | SYK (0.51) | SYKFERAURKB | |
| SCHEMBL6155734 | 0.91 | SYK (0.51) | SYKFERAURKB | |
| SCHEMBL6155319 | 0.80 | SYK (0.57) | SYKAURKB | |
| SCHEMBL6155315 | 0.80 | SYK (0.57) | SYKAURKB | |
| SCHEMBL6158656 | 0.80 | SYK (0.46) | SYKFERAURKB | |
| SCHEMBL6158662 | 0.80 | SYK (0.46) | SYKFERAURKB | |
| SCHEMBL1988785 | 0.75 | SYK (0.49) | SYKFERAURKB | |
| SCHEMBL23397913 | 0.73 | SYK (0.53) | SYKFERAURKB | |
| SCHEMBL1986849 | 0.73 | SYK (0.53) | SYKFERAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1184376-B1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-02-02 | — | — | EP | disclosed |
| US-6797706-B1 | Heterocyclecarboxamide derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2004-09-28 | — | — | US | disclosed |
| EP-1184376-A1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-03-06 | — | — | EP | disclosed |