SCHEMBL6155341

SCHEMBL6155341

CC(C)(O)CCCCc1cccc(C=Cc2ccc(C(O)O)cc2)c1

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 1/20 0.54
HDAC4 P56524 1/20 0.39
MEF2D Q14814 1/20 0.39
VDR P11473 7/20 0.37
CYP24A1 Q07973 2/20 0.36
LMNA P02545 1/20 0.36
PKM P14618 1/20 0.36
HTT P42858 1/20 0.36
PLAU P00749 1/20 0.34
LPL P06858 1/20 0.33
LIPG Q9Y5X9 1/20 0.33
CYP4F2 P78329 1/20 0.33
CYP4A11 Q02928 1/20 0.33
PPARG P37231 1/20 0.33
PPARA Q07869 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2108299 0.99 HMGCR (0.53) HMGCRHDAC4MEF2DVDRCYP24A1
SCHEMBL2106866 0.91 HMGCR (0.55) HMGCRHDAC4MEF2DVDRCYP24A1
SCHEMBL6154939 0.90 HMGCR (0.54) HMGCRHDAC4MEF2DVDRCYP24A1
SCHEMBL6155540 0.87 SPHK1 (0.41) HMGCRVDRCYP24A1LMNAPKM
SCHEMBL2107468 0.85 SPHK1 (0.40) HMGCRVDRCYP24A1LMNAPKM
SCHEMBL2107968 0.84 HMGCR (0.55) HMGCRHDAC4MEF2DVDRCYP24A1
SCHEMBL2107967 0.84 HMGCR (0.55) HMGCRHDAC4MEF2DVDRCYP24A1
SCHEMBL2107473 0.81 HMGCR (0.55) HMGCRHDAC4VDRLMNAPKM
SCHEMBL2107474 0.81 HMGCR (0.55) HMGCRHDAC4VDRLMNAPKM
SCHEMBL2108149 0.81 HMGCR (0.57) HMGCR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1124779-B1 VITAMIN D ANALOGUES GALDERMA RES & DEV (FR) 2005-02-02 EP claimed
US-6689922-B1 BIAROMATIC COMPOUNDS WHICH ARE ANALOGUES OF VITAMIN D HAVE A MARKED ACTIVITY IN THE FIELDS OF CELL DIFFERENTIATION AND PROLIFERATION GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) 2004-02-10 US claimed
EP-1124779-B1 VITAMIN D ANALOGUES GALDERMA RES & DEV (FR) 2005-02-02 EP disclosed
US-6689922-B1 BIAROMATIC COMPOUNDS WHICH ARE ANALOGUES OF VITAMIN D HAVE A MARKED ACTIVITY IN THE FIELDS OF CELL DIFFERENTIATION AND PROLIFERATION GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) 2004-02-10 US disclosed
EP-1124779-A1 VITAMIN D ANALOGUES Galderma Research & Development, S.N.C. (FR) 2001-08-22 EP disclosed
WO-2000026167-A1 VITAMIN D ANALOGUES GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2000-05-11 WO disclosed