Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154587 | 0.99 | HDAC8 (0.44) | SLC6A2HDAC8HDAC3HDAC6HDAC1 | |
| SCHEMBL30850132 | 0.85 | SLC6A2 (0.45) | SLC6A2SLC6A4 | |
| SCHEMBL10774534 | 0.76 | SLC6A2 (0.51) | SLC6A2SLC6A4 | |
| SCHEMBL11168356 | 0.75 | SLC6A2 (0.50) | SLC6A2SLC6A4CNR1CNR2 | |
| SCHEMBL22810523 | 0.75 | SLC6A2 (0.50) | SLC6A2SLC6A4 | |
| SCHEMBL30641461 | 0.74 | SLC6A2 (0.50) | SLC6A2SLC6A4CYP1A2CYP3A4MAPK1 | |
| SCHEMBL23940244 | 0.74 | SLC6A2 (0.52) | SLC6A2SLC6A4 | |
| SCHEMBL23940127 | 0.74 | SLC6A2 (0.49) | SLC6A2SLC6A4 | |
| SCHEMBL28585172 | 0.73 | SLC6A2 (0.46) | SLC6A2SLC6A4 | |
| SCHEMBL10575200 | 0.73 | LMNA (0.49) | SLC6A2SLC6A4CYP1A2CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358168-B1 | TRICYCLIC LACTAM AND SULTAM DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2005-08-10 | — | — | EP | disclosed |