Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437372 | 0.83 | GAA (0.56) | GAASIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL7437964 | 0.83 | GAA (0.56) | GAASIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8425972 | 0.80 | KMT2A (0.48) | GAASIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL6720949 | 0.80 | SIGMAR1 (0.64) | GAASIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL10577877 | 0.76 | SIGMAR1 (0.58) | GAASIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL6155789 | 0.76 | GAA (0.63) | GAASIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL7444111 | 0.69 | GAA (0.60) | GAASIGMAR1TAOK1KDM4EGSK3B | |
| SCHEMBL6720944 | 0.68 | SIGMAR1 (0.57) | GAASIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL15676743 | 0.68 | NPC1 (0.66) | GAAGRIN2DGRIN2CTAOK1KDM4E | |
| SCHEMBL6158192 | 0.68 | GAA (0.74) | GAASIGMAR1KDM4EGSK3BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0940139-B1 | Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers | SCION PHARMACEUTICALS INC (US) | 2005-02-02 | — | — | EP | disclosed |
| EP-0940139-A2 | Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers | CAMBRIDGE NEUROSCIENCE RESEARCH, INC. (US) | 1999-09-08 | — | — | EP | disclosed |