Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 12/20 | 0.54 |
| ▸ | THRA | P10827 | 9/20 | 0.54 |
| ▸ | RORC | P51449 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5283826 | 0.82 | THRB (0.60) | THRBTHRARORC | |
| SCHEMBL2788081 | 0.81 | THRB (0.73) | THRBTHRARORC | |
| SCHEMBL5276573 | 0.81 | THRB (0.74) | THRBTHRARORC | |
| SCHEMBL7119529 | 0.81 | KMT2A (0.45) | THRBTHRA | |
| SCHEMBL7054452 | 0.81 | THRB (0.57) | THRBTHRARORC | |
| SCHEMBL5355832 | 0.81 | THRB (0.61) | THRBTHRARORC | |
| SCHEMBL7076989 | 0.80 | THRB (0.73) | THRBTHRARORC | |
| SCHEMBL5618343 | 0.80 | THRB (0.60) | THRBTHRARORC | |
| SCHEMBL3886566 | 0.80 | THRB (0.57) | THRBTHRARORC | |
| SCHEMBL5363051 | 0.80 | THRB (0.58) | THRBTHRARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499578-A2 | PRIME RING SUBSTITUTED THYROID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CARDIAC AND METABOLIC DISORDERS | KARO BIO AB (SE) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003018515-A2 | PRIME RING SUBSTITUTED THYROID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CARDIAC AND METABOLIC DISORDERS | KARO BIO AB (SE) | 2003-03-06 | — | — | WO | disclosed |