⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17527696 | 1.00 | — | — | |
| Sulfuric Acid SCHEMBL11555536 | 0.88 | HSD17B10 (0.44) | — | |
| Sulfuric Acid SCHEMBL11555534 | 0.88 | HSD17B10 (0.44) | — | |
| SCHEMBL3582821 | 0.78 | — | — | |
| SCHEMBL1794235 | 0.74 | NOS1 (0.40) | — | |
| Water SCHEMBL11598887 | 0.72 | NOS1 (0.39) | — | |
| Hydrochloric Acid SCHEMBL7478514 | 0.70 | CYP1A2 (0.32) | — | |
| Sulfuric Acid SCHEMBL11558869 | 0.69 | NPSR1 (0.42) | — | |
| Sulfuric Acid SCHEMBL11558870 | 0.69 | NPSR1 (0.42) | — | |
| SCHEMBL41112 | 0.69 | NOS1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0940139-B1 | Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers | SCION PHARMACEUTICALS INC (US) | 2005-02-02 | — | — | EP | disclosed |
| EP-0517852-B1 | TRI- AND TETRA-SUBSTITUTED GUANIDINES AND THEIR USE AS EXCITATORY AMINO ACID ANTAGONISTS | OREGON STATE (US) | 2002-07-10 | — | — | EP | disclosed |
| US-6071969-A | ADMINISTERING AMINOGUANIDINE DERIVATIVE TO MAMMAL FOR TREATING OR PREVENTING DISEASE OF NERVOUS SYSTEM IN WHICH PATHOPHYSIOLOGY OF DISORDER INVOLVES EXCESSIVE RELEASE OF OF NEUROTRANSMITTER FROM NEURONAL CELLS | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-06-06 | — | — | US | disclosed |
| EP-0584088-B1 | SUBSTITUTED GUANIDINES AND DERIVATIVES THEREOF AS MODULATORS OF NEUROTRANSMITTER RELEASE AND NOVEL METHODOLOGY FOR IDENTIFYING NEUROTRANSMITTER RELEASE BLOCKERS | CAMBRIDGE NEUROSCIENCE RES (US) | 1999-10-27 | — | — | EP | disclosed |
| EP-0940139-A2 | Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers | CAMBRIDGE NEUROSCIENCE RESEARCH, INC. (US) | 1999-09-08 | — | — | EP | disclosed |
| US-5837737-A | MODULATOR OF NEUROTRANSMITTERS | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1998-11-17 | — | — | US | disclosed |
| US-5798390-A | Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON (US) | 1998-08-25 | — | — | US | disclosed |
| US-5767162-A | NERVOUS SYSTEM DISORDERS, BRAIN DISORDERS | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON (US) | 1998-06-16 | — | — | US | disclosed |
| US-5741661-A | SCREENING ASSAY | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1998-04-21 | — | — | US | disclosed |
| US-5686495-A | Substituted hydrazinedicarboximidamides and methods of use thereof | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5262568-A | Neuroprotective compounds, high binding affinity for phencyclidine, nervous system disorders | STATE OF OREGON (US) | 1993-11-16 | — | — | US | disclosed |
| US-5190976-A | Neuroprotective | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND UNIVERSITY OF OREGON (US) | 1993-03-02 | — | — | US | disclosed |
| EP-0517852-A1 | TRI- AND TETRA-SUBSTITUTED GUANIDINES AND THEIR USE AS EXCITATORY AMINO ACID ANTAGONISTS | STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON (US) | 1992-12-16 | — | — | EP | disclosed |
| WO-1992014697-A1 | SUBSTITUTED GUANIDINES AND DERIVATIVES THEREOF AS MODULATORS OF NEUROTRANSMITTER RELEASE AND NOVEL METHODOLOGY FOR IDENTIFYING NEUROTRANSMITTER RELEASE BLOCKERS | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1992-09-03 | — | — | WO | disclosed |
| US-5093525-A | Neuroprotective agents | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY (US) | 1992-03-03 | — | — | US | disclosed |
| WO-1991012797-A1 | TRI- AND TETRA-SUBSTITUTED GUANIDINES AND THEIR USE AS EXCITATORY AMINO ACID ANTAGONISTS | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALF SCIENCES UNIVERSITY (US) | 1991-09-05 | — | — | WO | disclosed |
| US-4906779-A | N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY (US) | 1990-03-06 | — | — | US | disclosed |
| EP-0314690-A4 | SIGMA BRAIN RECEPTOR LIGANDS AND THEIR USE. | OREGON STATE (US) | 1989-11-07 | — | — | EP | disclosed |
| EP-0314690-A1 | SIGMA BRAIN RECEPTOR LIGANDS AND THEIR USE. | OREGON STATE (US) | 1989-05-10 | — | — | EP | disclosed |
| WO-1988000583-A1 | SIGMA BRAIN RECEPTOR LIGANDS AND THEIR USE | STATE OF OREGON ACTING BY AND THROUGH THE STATE BO (US) | 1988-01-28 | — | — | WO | disclosed |