Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 13/20 | 0.47 |
| ▸ | PNP | P00491 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7327169 | 0.99 | TLR8 (0.46) | TLR8PNPKDR | |
| Hydrochloric Acid SCHEMBL7382279 | 0.86 | TLR8 (0.45) | TLR8PNPKDR | |
| SCHEMBL7738861 | 0.74 | POLB (0.41) | TLR8 | |
| Hydrochloric Acid SCHEMBL7734161 | 0.73 | TLR8 (0.42) | TLR8KDR | |
| SCHEMBL6155946 | 0.71 | KDM4E (0.47) | PNP | |
| SCHEMBL29157955 | 0.67 | ADORA2A (0.64) | — | |
| SCHEMBL14243368 | 0.64 | TLR8 (0.46) | TLR8 | |
| SCHEMBL6673868 | 0.64 | ALDH1A1 (0.42) | TLR8KDR | |
| SCHEMBL16512992 | 0.64 | TLR8 (1.00) | TLR8 | |
| SCHEMBL9469935 | 0.63 | TLR8 (0.47) | TLR8KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912575-B1 | PROCESSES FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY | EURO CELTIQUE SA (LU) | 2005-02-02 | — | — | EP | claimed |
| EP-0912575-A4 | IMPROVED METHODS FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY | EURO CELTIQUE SA (LU) | 2001-04-25 | — | — | EP | claimed |
| EP-0912575-A1 | IMPROVED METHODS FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY | Euro-Celtique S.A. (LU) | 1999-05-06 | — | — | EP | claimed |
| US-5864037-A | Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity | EURO-CELTIQUE, S.A. (LU) | 1999-01-26 | — | — | US | claimed |
| WO-1997046561-A1 | IMPROVED METHODS FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY | EURO-CELTIQUE, S.A. (LU) | 1997-12-11 | — | — | WO | claimed |