Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6157246 | 1.00 | CASP1 (0.58) | CASP1KMT2AHPGDALDH1A1CYP2D6 | |
| SCHEMBL6157251 | 1.00 | CASP1 (0.58) | CASP1KMT2AHPGDALDH1A1CYP2D6 | |
| SCHEMBL6160436 | 0.86 | CASP1 (0.77) | CASP1KMT2AHPGDALDH1A1 | |
| SCHEMBL6160430 | 0.86 | CASP1 (0.77) | CASP1KMT2AHPGDALDH1A1 | |
| SCHEMBL6160428 | 0.86 | CASP1 (0.77) | CASP1KMT2AHPGDALDH1A1 | |
| SCHEMBL27561937 | 0.75 | KMT2A (0.68) | CASP1KMT2AHPGDALDH1A1CYP2D6 | |
| SCHEMBL6158236 | 0.75 | KMT2A (0.68) | CASP1KMT2AHPGDALDH1A1CYP2D6 | |
| SCHEMBL27541292 | 0.74 | KMT2A (0.60) | CASP1KMT2AHPGDALDH1A1CYP2D6 | |
| SCHEMBL6157277 | 0.74 | KMT2A (0.60) | CASP1KMT2AHPGDALDH1A1CYP2D6 | |
| SCHEMBL6157640 | 0.74 | CASP1 (1.00) | CASP1KMT2AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | disclosed |
| EP-1082127-A4 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1082127-A1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999056765-A1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1999-11-11 | — | — | WO | disclosed |