SCHEMBL6157403

SCHEMBL6157403

CC(C)C(CC(=O)N(C)CCn1cnc2ccccc21)C(=O)NC(C=O)CC(=O)O

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 18/20 0.73
EGLN3 Q9H6Z9 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6160442 0.88 CASP1 (0.73) CASP1
SCHEMBL6158833 0.85 CASP1 (1.00) CASP1
SCHEMBL6158675 0.84 CASP1 (0.73) CASP1
SCHEMBL6158852 0.82 CASP1 (0.63) CASP1
SCHEMBL6158247 0.78 CASP1 (0.80) CASP1
SCHEMBL6159206 0.78 CASP1 (0.53) CASP1
SCHEMBL6160210 0.78 CASP1 (0.57) CASP1
SCHEMBL6159743 0.72 CASP1 (0.52) CASP1
SCHEMBL7420589 0.72 CASP1 (0.51) CASP1
SCHEMBL6160462 0.72 CASP1 (0.53) CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1082127-B1 SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME WARNER LAMBERT CO (US) 2005-06-22 EP claimed
EP-1082127-B1 SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME WARNER LAMBERT CO (US) 2005-06-22 EP disclosed
EP-1082127-A4 SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME WARNER LAMBERT CO (US) 2002-10-09 EP disclosed
EP-1082127-A1 SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME WARNER-LAMBERT COMPANY (US) 2001-03-14 EP disclosed
WO-1999056765-A1 SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME WARNER-LAMBERT COMPANY (US) 1999-11-11 WO disclosed