Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.35 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1388273 | 0.99 | CCNA2 (0.41) | CCNA2CDK2CCNA1CACNA1BCACNA1A | |
| SCHEMBL1388150 | 0.85 | PDE10A (0.44) | CCNA2CDK2CCNA1ADORA2AADORA1 | |
| Hydrochloric Acid SCHEMBL7022609 | 0.84 | PDE10A (0.43) | CCNA2CDK2CCNA1PDE10ACTSL | |
| SCHEMBL1387934 | 0.84 | PDE4A (0.42) | CTSLCTSB | |
| SCHEMBL1388096 | 0.83 | PDE10A (0.39) | CCNA2CDK2CCNA1CDK1ADORA2A | |
| Hydrochloric Acid SCHEMBL7022799 | 0.83 | CTSL (0.41) | CTSLCTSB | |
| SCHEMBL5964495 | 0.82 | CTSL (0.47) | ADORA2AADORA1ADORA3PDE10ACTSL | |
| SCHEMBL1387911 | 0.82 | PDE10A (0.40) | ADORA2AADORA1PDE10ACTSLCTSB | |
| SCHEMBL6157541 | 0.81 | PDE10A (0.39) | CDK1CCNB1ADORA2AADORA1PDE10A | |
| Hydrochloric Acid SCHEMBL7031819 | 0.81 | PDE10A (0.39) | ADORA2AADORA1PDE10ACTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912575-B1 | PROCESSES FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY | EURO CELTIQUE SA (LU) | 2005-02-02 | — | — | EP | claimed |
| US-5939422-A | AN ENZYME INHIBITOR AS BRONCHODILATOR, RELAXANTS, ANTIINFLAMMATORY AGENT FOR TREATING ASTHMA, ALLERGIES, INFLAMMATION, DEPRESSION, DEMENTIA, DISEASES ASSOCIATED WITH ABNORMAL HIGH LEVEL OF CYTOKINE | EURO-CELTIQUE, S.A. (LU) | 1999-08-17 | — | — | US | claimed |
| US-5864037-A | Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity | EURO-CELTIQUE, S.A. (LU) | 1999-01-26 | — | — | US | claimed |
| US-6413975-B1 | DISEASES WITH HIGH LEVELS OF INFLAMMATORY CYTOKINES; ASTHMA; ALLERGIES; INFLAMMATION; DEPRESSION; ALZHEIMER'S DISEASE; VASCULAR AND MULTI-IN-FARCT DEMENTIA | EURO-CELTIQUE, S.A. (LU) | 2002-07-02 | — | — | US | disclosed |
| US-6294541-B1 | ENZYME INHIBITORS USING PURINE COMPOUNDS AS ANTIHISTAMINES | EURO-CELTIQUE S.A. (LU) | 2001-09-25 | — | — | US | disclosed |