Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 12/20 | 0.61 |
| ▸ | AURKA | O14965 | 3/20 | 0.61 |
| ▸ | CDK1 | P06493 | 3/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.61 |
| ▸ | GSK3B | P49841 | 3/20 | 0.61 |
| ▸ | FLT3 | P36888 | 2/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.61 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.61 |
| ▸ | CDC7 | O00311 | 1/20 | 0.61 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | IKBKB | O14920 | 1/20 | 0.61 |
| ▸ | CHUK | O15111 | 1/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.61 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14562071 | 0.88 | PIK3CG (0.64) | CDK2AURKACDK1AURKBGSK3B | |
| SCHEMBL6156552 | 0.88 | CDK2 (0.72) | CDK2AURKACDK1AURKBGSK3B | |
| SCHEMBL2285781 | 0.86 | CDK2 (0.67) | CDK2AURKACDK1AURKBGSK3B | |
| SCHEMBL2286476 | 0.85 | CDK2 (0.74) | CDK2AURKACDK1AURKBGSK3B | |
| SCHEMBL27741375 | 0.84 | CDK2 (0.62) | CDK2AURKACDK1AURKBGSK3B | |
| SCHEMBL27741365 | 0.84 | CDK2 (0.60) | CDK2AURKACDK1AURKBGSK3B | |
| SCHEMBL2286543 | 0.83 | PIK3CG (0.61) | CDK2AURKACDK1AURKBGSK3B | |
| SCHEMBL4803155 | 0.82 | CDK2 (0.71) | CDK2AURKACDK1AURKBGSK3B | |
| SCHEMBL6161270 | 0.82 | CDK2 (0.78) | CDK2AURKACDK1AURKBGSK3B | |
| SCHEMBL2283576 | 0.81 | CDK2 (0.59) | CDK2AURKACDK1AURKBGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581231-A1 | ANTI-VIRAL COMPOUNDS | Cyclacel Limited (GB) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004043467-A1 | ANTI-VIRAL COMPOUNDS | CYCLACEL LIMITED (GB) | 2004-05-27 | — | — | WO | disclosed |