Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 18/20 | 0.48 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | IL1B | P01584 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160694 | 0.79 | CRBN (0.47) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL31090662 | 0.73 | DDB1 (0.61) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL24744845 | 0.73 | DDB1 (0.61) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL31090564 | 0.73 | DDB1 (0.61) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL24744852 | 0.73 | DDB1 (0.61) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL24744843 | 0.73 | DDB1 (0.61) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL24746778 | 0.73 | DDB1 (0.61) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL24744848 | 0.73 | DDB1 (0.61) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL31090622 | 0.73 | DDB1 (0.61) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL31090626 | 0.73 | DDB1 (0.61) | CRBNDDB1IKZF3ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062210-B1 | 1,2-DIAZEPANE DERIVATIVES AS INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITORS | VERTEX PHARMA (US) | 2005-06-01 | — | — | EP | disclosed |
| US-6426413-B1 | SUCH AS (N-BENZYLOXYCARBONYL-HYDRAZINO)-ACETIC ACID TERT-BUTYL ESTER; FOR PREVENTING AND TREATING INTERLEUKIN-MEDIATED DISEASES, APOPTOSIS, AUTOIMMUNE DISEASES, BONE DISORDERS, PROLIFERATIVE DISORDERS, INFECTIONS, AND DEGENERATIVE DISEASES | VERTEX PHARMACEUTICALS INCORPORATED | 2002-07-30 | — | — | US | disclosed |