Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.50 |
| ▸ | CBX7 | O95931 | 3/20 | 0.44 |
| ▸ | CDYL2 | Q8N8U2 | 3/20 | 0.44 |
| ▸ | CDYL | Q9Y232 | 3/20 | 0.44 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371414 | 0.73 | PDE4B (0.45) | PDE4BCBX7CDYL2CDYLCDY1; CDY1B | |
| SCHEMBL5563554 | 0.71 | ALDH1A1 (0.55) | PDE4BMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL5564330 | 0.69 | PDE4B (0.55) | PDE4BCBX7CDYL2CDYLCDY1; CDY1B | |
| SCHEMBL18313965 | 0.68 | ALDH1A1 (0.57) | PDE4BMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL22713897 | 0.67 | PDE4B (1.00) | PDE4B | |
| SCHEMBL22713918 | 0.65 | PDE4B (1.00) | PDE4B | |
| SCHEMBL6073307 | 0.65 | MAPK1 (0.55) | MAPTALDH1A1 | |
| SCHEMBL22714024 | 0.65 | PDE4B (1.00) | PDE4B | |
| SCHEMBL22713955 | 0.65 | PDE4B (1.00) | PDE4B | |
| SCHEMBL7285107 | 0.65 | CTNNB1 (0.58) | PDE4BMAPTALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832071-B1 | 1,3-DIHYDRO-2H-IMIDAZOL-2-ONE DERIVATIVES HAVING PDE IV AND CYTOKININ INHIBITING ACTIVITY | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-28 | — | — | EP | disclosed |
| US-5869515-A | TREATING ASTHMATIC OR ATOPIC DISEASES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-02-09 | — | — | US | disclosed |
| EP-0832071-A1 | 1,3-DIHYDRO-2H-IMIDAZOL-2-ONE DERIVATIVES HAVING PDE IV AND CYTOKININ INHIBITING ACTIVITY | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996031487-A1 | 1,3-DIHYDRO-2H-IMIDAZOL-2-ONE DERIVATIVES HAVING PDE IV AND CYTOKININ INHIBITING ACTIVITY | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-10-10 | — | — | WO | disclosed |