Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 6/20 | 0.56 |
| ▸ | TLR2 | O60603 | 4/20 | 0.55 |
| ▸ | MDM4 | O15151 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8893047 | 0.91 | MDM2 (0.60) | MDM2TLR2MDM4TP53HDAC1 | |
| SCHEMBL8892538 | 0.91 | MDM2 (0.60) | MDM2TLR2MDM4TP53HDAC1 | |
| SCHEMBL13038839 | 0.89 | MDM2 (0.58) | MDM2TLR2MDM4TP53CASP3 | |
| SCHEMBL6157217 | 0.89 | HDAC1 (0.61) | MDM2TLR2HDAC1HDAC2 | |
| SCHEMBL25361805 | 0.88 | TLR2 (0.59) | MDM2TLR2MDM4TP53CASP3 | |
| SCHEMBL16745562 | 0.88 | TLR2 (0.56) | MDM2TLR2MDM4TP53HDAC1 | |
| SCHEMBL25361808 | 0.88 | TLR2 (0.59) | MDM2TLR2MDM4TP53CASP3 | |
| SCHEMBL8425079 | 0.88 | MDM2 (0.55) | MDM2TLR2MDM4TP53HDAC1 | |
| SCHEMBL25362302 | 0.87 | MDM2 (0.57) | MDM2TLR2MDM4TP53CASP3 | |
| SCHEMBL30854537 | 0.87 | MDM2 (0.57) | MDM2TLR2MDM4TP53CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1504094-A2 | PEPTIDE COMPOUNDS AND THEIR USE AS PROTEASE SUBSTRATES | Pharmacia Corporation (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003095475-A2 | PEPTIDE COMPOUNDS AND THEIR USE AS PROTEASE SUBSTRATES | PHARMACIA CORPORATION (US) | 2003-11-20 | — | — | WO | disclosed |