SCHEMBL6159067

SCHEMBL6159067

CCCC1CCc2cc(-c3cc(F)c(F)c(F)c3)ccc2C1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1D P28221 1/20 0.39
HTR1B P28222 1/20 0.39
CYP3A4 P08684 3/20 0.38
CYP2C8 P10632 2/20 0.38
S1PR3 Q99500 2/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
DGAT1 O75907 1/20 0.38
CYP1A2 P05177 4/20 0.37
CYP11B1 P15538 4/20 0.37
CYP11B2 P19099 4/20 0.37
MCHR1 Q99705 3/20 0.36
FYN P06241 1/20 0.36
CYP19A1 P11511 2/20 0.34
CYP26A1 O43174 1/20 0.34
CYP2B6 P20813 1/20 0.34
BACE1 P56817 1/20 0.34
S1PR1 P21453 2/20 0.33
SGPL1 O95470 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14526308 0.99 DGAT1 (0.40) HTR1DHTR1BCYP3A4CYP2C8S1PR3
SCHEMBL14526545 0.96 CYP3A4 (0.39) HTR1DHTR1BCYP3A4CYP2C8S1PR3
SCHEMBL14525833 0.91 CYP3A4 (0.48) HTR1DHTR1BCYP3A4CYP2C8S1PR3
SCHEMBL6157914 0.90 HTR1D (0.40) HTR1DHTR1BCYP3A4CYP2C8S1PR3
SCHEMBL17356636 0.90 HTR1D (0.36) HTR1DHTR1BCYP3A4CYP2C8S1PR3
SCHEMBL14526311 0.88 CYP1A2 (0.36) HTR1DHTR1BCYP3A4CYP2C8S1PR3
SCHEMBL14526546 0.88 CYP3A4 (0.48) HTR1DHTR1BCYP3A4CYP2C8S1PR3
SCHEMBL6158506 0.88 HTR1D (0.43) HTR1DHTR1BCYP3A4CYP2C8S1PR3
SCHEMBL14526310 0.87 DGAT1 (0.36) HTR1DHTR1BCYP3A4CYP2C8S1PR3
SCHEMBL14525807 0.86 CYP3A4 (0.33) HTR1DHTR1BCYP3A4CYP2C8S1PR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7198827-B1 Nematic liquid crystal composition and liquid crystal display device using the same DAINIPPON INK AND CHEMICALS, INC. (JP) 2007-04-03 US disclosed
US-7198827-B1 Nematic liquid crystal composition and liquid crystal display device using the same DAINIPPON INK AND CHEMICALS, INC. (JP) 2007-04-03 US disclosed
EP-1191008-B1 COMPOUND HAVING TETRAHYDRONAPHTHALENE SKELETON AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME DAINIPPON INK & CHEMICALS (JP) 2005-02-09 EP disclosed
US-6746728-B1 SUPERIOR LIQUID CRYSTALLINITY AND CO-SOLUBILITY WITH CURRENTLY USED LIQUID CRYSTAL COMPOUNDS; TEMPERATURE RANGE OVER WHICH LIQUID CRYSTALLINITY IS SHOWN IS BROAD; THRESHOLD VOLTAGE IS LOW; CAPABLE OF HIGH SPEED RESPONSE DAINIPPON INK AND CHEMICALS, INC. (JP) 2004-06-08 US disclosed
EP-1191008-A1 COMPOUND HAVING TETRAHYDRONAPHTHALENE SKELETON AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME DAINIPPON INK AND CHEMICALS, INC. (JP) 2002-03-27 EP disclosed