Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | BCR | P11274 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7164212 | 0.99 | AURKA (0.35) | AURKAAURKBPSEN1PSEN2APH1B | |
| SCHEMBL7858511 | 0.92 | AURKA (0.36) | AURKAAURKBPSEN1PSEN2APH1B | |
| SCHEMBL6158156 | 0.92 | KMT2A (0.40) | AURKAAURKBMEN1BLMKMT2A | |
| Hydrochloric Acid SCHEMBL6158829 | 0.91 | AURKA (0.35) | AURKAAURKBPSEN1PSEN2APH1B | |
| Hydrochloric Acid SCHEMBL6157511 | 0.91 | KMT2A (0.39) | AURKAAURKBMEN1BLMKMT2A | |
| SCHEMBL7836074 | 0.90 | MEN1 (0.35) | AURKAAURKBMEN1BLMKMT2A | |
| SCHEMBL6157935 | 0.90 | AURKA (0.38) | AURKAAURKBMEN1KMT2AABL1 | |
| Hydrochloric Acid SCHEMBL6159137 | 0.90 | MEN1 (0.34) | AURKAAURKBMEN1BLMKMT2A | |
| Hydrochloric Acid SCHEMBL7164270 | 0.89 | MEN1 (0.38) | AURKAAURKBMEN1KMT2AABL1 | |
| SCHEMBL7822656 | 0.89 | AURKA (0.36) | AURKAAURKBJAK2ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131312-B1 | NOVEL PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORP LTD (KR) | 2005-10-26 | — | — | EP | disclosed |