Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90B1 | P14625 | 5/20 | 0.33 |
| ▸ | DHODH | Q02127 | 4/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973041 | 0.90 | HSP90B1 (0.35) | HSP90B1GCGRALDH1A1HPGDTRAP1 | |
| SCHEMBL6961520 | 0.90 | HSP90B1 (0.32) | HSP90B1GCGRTRAP1HSP90AA1HSP90AB1 | |
| SCHEMBL6961950 | 0.89 | HSP90B1 (0.30) | HSP90B1TRAP1HSP90AA1HSP90AB1 | |
| SCHEMBL6962277 | 0.89 | KMT2A (0.33) | HSP90B1TRAP1HSP90AA1HSP90AB1 | |
| SCHEMBL6968701 | 0.88 | TLR8 (0.36) | HSP90B1GCGRALDH1A1TRAP1HSP90AA1 | |
| SCHEMBL6966836 | 0.88 | HSP90B1 (0.43) | HSP90B1GCGRALDH1A1TRAP1HSP90AA1 | |
| SCHEMBL6961885 | 0.88 | TP53 (0.37) | DHODH | |
| SCHEMBL6968487 | 0.88 | HSP90AA1 (0.30) | HSP90B1TRAP1HSP90AA1HSP90AB1 | |
| SCHEMBL6957208 | 0.87 | HSP90B1 (0.35) | HSP90B1TRAP1HSP90AA1HSP90AB1 | |
| SCHEMBL7081625 | 0.86 | HSP90B1 (0.39) | HSP90B1GCGRTRAP1HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | claimed |
| EP-0893442-B1 | LYMPH-ABSORBABLE IMIDAZOLE DERIVATIVES | SHIONOGI & CO (JP) | 2005-01-12 | — | — | EP | disclosed |
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-6054591-A | LYMPHOTROPIC ANTI-AIDS AGENT | SHIONOGI & CO., LTD. (JP) | 2000-04-25 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0893442-A1 | LYMPH-ABSORBABLE IMIDAZOLE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 1999-01-27 | — | — | EP | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |