Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.52 |
| ▸ | MME | P08473 | 4/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160866 | 1.00 | ACE (0.52) | ACEMMEHRH4ABL1BCR | |
| SCHEMBL6574501 | 0.88 | MME (0.66) | MMEHRH4 | |
| SCHEMBL6161590 | 0.88 | MME (0.66) | MMEHRH4 | |
| SCHEMBL6161582 | 0.88 | MME (0.66) | MMEHRH4 | |
| SCHEMBL3410335 | 0.88 | MME (0.66) | MMEHRH4 | |
| SCHEMBL7315829 | 0.88 | MME (0.66) | MMEHRH4 | |
| SCHEMBL6161489 | 0.83 | MME (0.56) | MMEHRH4 | |
| SCHEMBL6161839 | 0.83 | MME (0.56) | MMEHRH4 | |
| SCHEMBL6161755 | 0.82 | ABL1 (0.42) | ACEABL1BCR | |
| SCHEMBL6161753 | 0.82 | ABL1 (0.42) | ACEABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877740-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2005-03-30 | — | — | EP | disclosed |