Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 12/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21820786 | 0.69 | HSP90AA1 (0.71) | HSP90AA1HAO1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6161454 | 0.66 | HSP90AA1 (0.40) | HSP90AA1HAO1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL968876 | 0.64 | — | — | |
| SCHEMBL693602 | 0.61 | HSP90AA1 (0.55) | HSP90AA1HAO1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11176772 | 0.61 | HSP90AA1 (0.55) | HSP90AA1HAO1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7179951 | 0.61 | HSP90AA1 (0.48) | HSP90AA1HAO1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4618582 | 0.61 | — | — | |
| SCHEMBL11171271 | 0.60 | SLC6A4 (0.42) | HSP90AA1HAO1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL10614755 | 0.60 | KMO (0.62) | HSP90AA1HAO1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL26623383 | 0.60 | HSP90AA1 (0.48) | HSP90AA1HAO1SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377550-B9 | PHENYL HETEROCYCLYL ETHER DERIVATIVES AS SEROTONIN RE-UPTAKE INHIBITORS | PFIZER LTD (GB) | 2005-11-23 | — | — | EP | disclosed |
| EP-1377550-B1 | PHENYL HETEROCYCLYL ETHER DERIVATIVES AS SEROTONIN RE-UPTAKE INHIBITORS | PFIZER LTD (GB) | 2004-11-03 | — | — | EP | disclosed |