Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.80 |
| ▸ | HTR2A | P28223 | 4/20 | 0.80 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.80 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.80 |
| ▸ | HTR2B | P41595 | 2/20 | 0.80 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.80 |
| ▸ | HTR1A | P08908 | 1/20 | 0.80 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.80 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | HTR3A | P46098 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 2/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 5/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3195832 | 0.91 | ADRA2C (0.82) | ADRA2CSLC6A4HTR2ASLC6A2SLC6A3 | |
| (R)-Viloxazine SCHEMBL2524727 | 0.89 | SLC6A4 (1.00) | ADRA2CSLC6A4HTR2ASLC6A2SLC6A3 | |
| (S)-Viloxazine SCHEMBL31126415 | 0.89 | SLC6A4 (1.00) | ADRA2CSLC6A4HTR2ASLC6A2SLC6A3 | |
| Viloxazine SCHEMBL34168 | 0.89 | SLC6A4 (1.00) | ADRA2CSLC6A4HTR2ASLC6A2SLC6A3 | |
| (S)-Viloxazine SCHEMBL2524730 | 0.89 | SLC6A4 (1.00) | ADRA2CSLC6A4HTR2ASLC6A2SLC6A3 | |
| Viloxazine SCHEMBL29359040 | 0.89 | SLC6A4 (1.00) | ADRA2CSLC6A4HTR2ASLC6A2SLC6A3 | |
| (R)-Viloxazine SCHEMBL30589854 | 0.89 | SLC6A4 (1.00) | ADRA2CSLC6A4HTR2ASLC6A2SLC6A3 | |
| (S)-Viloxazine SCHEMBL25394508 | 0.87 | SLC6A4 (0.97) | ADRA2CSLC6A4HTR2ASLC6A2SLC6A3 | |
| Viloxazine SCHEMBL300741 | 0.87 | SLC6A4 (0.97) | ADRA2CSLC6A4HTR2ASLC6A2SLC6A3 | |
| Viloxazine SCHEMBL29362568 | 0.87 | SLC6A4 (0.97) | ADRA2CSLC6A4HTR2ASLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920423-B1 | DISUBSTITUTED MORPHOLINE, OXAZEPINE OR THIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE D4 RECEPTOR ANTAGONISTS | NEUROSEARCH AS (DK) | 2005-01-26 | — | — | EP | disclosed |
| US-6479491-B1 | USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, ESPECIALLY PSYCHOTIC DISORDERS SUCH AS SCHIZOPHRENIA | NEUROSEARCH A/S (DK) | 2002-11-12 | — | — | US | disclosed |
| US-6207662-B1 | USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, PSYCHOTIC DISORDERS SUCH AS SCHIZOPHRENIA | NEUROSEARCH A/S (DK) | 2001-03-27 | — | — | US | disclosed |
| EP-0920423-A1 | DISUBSTITUTED MORPHOLINE, OXAZEPINE OR THIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE D4 RECEPTOR ANTAGONISTS | NEUROSEARCH A/S (DK) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998007710-A1 | DISUBSTITUTED MORPHOLINE, OXAZEPINE OR THIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE D4 RECEPTOR ANTAGONISTS | NEUROSEARCH A/S (DK) | 1998-02-26 | — | — | WO | disclosed |