Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 12/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 11/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 11/20 | 0.55 |
| ▸ | PTGIR | P43119 | 3/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
| ▸ | F12 | P00748 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 2/20 | 0.42 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6159252 | 0.99 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL6159397 | 0.88 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL6158020 | 0.87 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL6160643 | 0.86 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| Hydrochloric Acid SCHEMBL6159874 | 0.86 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL6159756 | 0.85 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL6159576 | 0.85 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| Hydrochloric Acid SCHEMBL6159435 | 0.84 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| SCHEMBL4759817 | 0.84 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CPTGIRAOC3 | |
| Hydrochloric Acid SCHEMBL6159918 | 0.84 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CPTGIRAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339694-B1 | SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE PHENYL KETONE DERIVATIVES AS IP ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-09-21 | — | — | EP | disclosed |