Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11262596 | 0.82 | TSHR (0.59) | KMT2AMEN1NPC1TSHRCYP1A2 | |
| SCHEMBL11129057 | 0.82 | TSHR (0.59) | KMT2AMEN1NPC1TSHRCYP1A2 | |
| SCHEMBL11239071 | 0.82 | TSHR (0.59) | KMT2AMEN1NPC1TSHRCYP1A2 | |
| SCHEMBL904248 | 0.80 | CTBP2 (0.60) | KMT2AMEN1NPC1RAB9AMMP13 | |
| SCHEMBL30342076 | 0.80 | CTBP2 (0.60) | KMT2AMEN1NPC1RAB9AMMP13 | |
| SCHEMBL27628173 | 0.76 | RAB9A (0.69) | KMT2AMEN1NPC1RAB9ATAAR1 | |
| SCHEMBL3101828 | 0.75 | NPC1 (0.60) | KMT2AL3MBTL1NPC1RAB9ATSHR | |
| SCHEMBL16284888 | 0.75 | NPC1 (0.60) | KMT2AL3MBTL1NPC1RAB9ATSHR | |
| SCHEMBL16284887 | 0.75 | NPC1 (0.60) | KMT2AL3MBTL1NPC1RAB9ATSHR | |
| SCHEMBL6672877 | 0.75 | NPC1 (0.60) | KMT2AL3MBTL1NPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877740-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2005-03-30 | — | — | EP | disclosed |
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | disclosed |
| US-5760241-A | ANGIOTENSIN CONVERTING ENZYME AND ENKEPHALINASE INHIBITORS; CARDIOVASCULAR DISORDERS | ZAMBON GROUP S.P.A. (IT) | 1998-06-02 | — | — | US | disclosed |