Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.69 |
| ▸ | FLT1 | P17948 | 1/20 | 0.69 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.65 |
| ▸ | EGFR | P00533 | 3/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.62 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162791 | 1.00 | KDR (0.69) | KDRFLT1ABCG2EGFRHDAC3 | |
| SCHEMBL6162938 | 0.91 | KDR (0.74) | KDRABCG2EGFRHDAC3HDAC1 | |
| SCHEMBL6163496 | 0.91 | KDR (0.70) | KDRABCG2EGFRHDAC3HDAC1 | |
| SCHEMBL6166357 | 0.91 | KDR (0.70) | KDRABCG2EGFRHDAC3HDAC1 | |
| SCHEMBL6162947 | 0.91 | KDR (0.74) | KDRABCG2EGFRHDAC3HDAC1 | |
| SCHEMBL6164812 | 0.86 | EGFR (0.66) | KDRABCG2EGFRHDAC3HDAC1 | |
| SCHEMBL6164827 | 0.86 | EGFR (0.66) | KDRABCG2EGFRHDAC3HDAC1 | |
| SCHEMBL6161899 | 0.86 | KDR (0.75) | KDRFLT1ABCG2EGFRHDAC3 | |
| SCHEMBL6163629 | 0.86 | KDR (0.75) | KDRFLT1ABCG2EGFRHDAC3 | |
| SCHEMBL6165229 | 0.86 | ABCG2 (0.64) | KDRABCG2EGFRHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218357-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-04-06 | — | — | EP | claimed |