SCHEMBL6161706

SCHEMBL6161706

c1ccc(Oc2cccc(N3CCN(C[C@@H]4C[C@H]4c4ccccc4)CC3)c2)cc1

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 20/20 0.78
DRD4 P21917 19/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6161120 0.80 DRD2 (0.74) DRD2DRD4
SCHEMBL7673425 0.76 DRD2 (0.97) DRD2DRD4
SCHEMBL7673432 0.76 DRD2 (0.97) DRD2DRD4
SCHEMBL6779580 0.75 DRD2 (0.75) DRD2DRD4
SCHEMBL14279081 0.75 DRD2 (0.67) DRD2DRD4
SCHEMBL6777189 0.75 DRD2 (0.67) DRD2DRD4
SCHEMBL6779645 0.75 DRD2 (0.67) DRD2DRD4
SCHEMBL6779582 0.75 DRD2 (0.75) DRD2DRD4
SCHEMBL6779639 0.75 DRD2 (0.67) DRD2DRD4
SCHEMBL6777987 0.75 DRD2 (0.67) DRD2DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0755923-B1 Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor DAIICHI SUNTORY PHARMA CO LTD (JP) 2005-05-04 EP disclosed
US-6469010-B1 COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD SUNTORY LIMITED (JP) 2002-10-22 US disclosed
US-6048876-A ANTICONVULSANTS; ANTIEPILEPIC AGENT SUNTORY LIMITED (JP) 2000-04-11 US disclosed
EP-0755923-A1 AMELIORANT OR REMEDY FOR SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND COMPOUNDS USEFUL THEREFOR SUNTORY LIMITED (JP) 1997-01-29 EP disclosed