Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.64 |
| ▸ | YAP1 | P46937 | 3/20 | 0.64 |
| ▸ | PPARG | P37231 | 2/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.62 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | REN | P00797 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.56 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.56 |
| ▸ | CTSS | P25774 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.56 |
| ▸ | CTSK | P43235 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3500186 | 1.00 | BCL2 (0.64) | BCL2YAP1PPARGPTPN1KLK5 | |
| SCHEMBL3350988 | 1.00 | BCL2 (0.64) | BCL2YAP1PPARGPTPN1KLK5 | |
| SCHEMBL7523637 | 0.93 | BCL2 (0.64) | BCL2YAP1PPARGPTPN1REN | |
| SCHEMBL9752770 | 0.93 | BCL2 (0.64) | BCL2YAP1PPARGPTPN1REN | |
| SCHEMBL9752771 | 0.93 | BCL2 (0.64) | BCL2YAP1PPARGPTPN1REN | |
| SCHEMBL18025361 | 0.92 | BCL2 (0.63) | BCL2YAP1PPARGPTPN1REN | |
| SCHEMBL3723164 | 0.91 | BCL2 (0.62) | BCL2YAP1PPARGPTPN1LMNA | |
| SCHEMBL15565651 | 0.91 | BCL2 (0.57) | BCL2YAP1PPARGPTPN1KLK5 | |
| SCHEMBL8415923 | 0.91 | REN (0.65) | BCL2YAP1PPARGPTPN1REN | |
| SCHEMBL3498507 | 0.91 | BCL2 (0.56) | BCL2YAP1PPARGPTPN1KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |
| EP-0828754-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER INC. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038471-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER INC. (US) | 1996-12-05 | — | — | WO | disclosed |
| WO-1996035713-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER, INC. (US) | 1996-11-14 | — | — | WO | disclosed |