SCHEMBL6161991

SCHEMBL6161991

Cc1ccc(CNC(=O)c2c[nH]c3c(c2=O)CCCC3)cc1

nearest known ligand 0.57

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 8/20 0.57
ADORA1 P30542 5/20 0.57
HPGD P15428 3/20 0.54
MAPT P10636 4/20 0.47
POLB P06746 3/20 0.47
LMNA P02545 2/20 0.47
KDM4E B2RXH2 3/20 0.46
ALDH1A1 P00352 2/20 0.46
TDP1 Q9NUW8 3/20 0.46
TP53 P04637 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HSD17B10 Q99714 1/20 0.44
IGF1R P08069 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6162507 0.89 ADORA2A (0.55) ADORA2AADORA1HPGDPOLBLMNA
SCHEMBL6162671 0.88 HPGD (0.55) ADORA2AADORA1HPGDPOLBLMNA
SCHEMBL6161944 0.88 ADORA2A (0.55) ADORA2AADORA1MAPTPOLBLMNA
SCHEMBL6160803 0.88 ADORA2A (0.55) ADORA2AADORA1MAPTPOLBALDH1A1
SCHEMBL6160635 0.88 KDM4E (0.50) ADORA2AADORA1HPGDMAPTPOLB
SCHEMBL6164599 0.87 ADORA2A (0.58) ADORA2AADORA1HPGDMAPTPOLB
SCHEMBL6162307 0.87 ADORA2A (0.54) ADORA2AADORA1HPGDMAPTPOLB
SCHEMBL6160996 0.86 ADORA2A (0.55) ADORA2AADORA1HPGDPOLBALDH1A1
SCHEMBL6162143 0.86 ADORA2A (0.57) ADORA2AADORA1HPGDMAPTPOLB
SCHEMBL6162159 0.86 ADORA2A (0.57) ADORA2AADORA1HPGDMAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1056724-B1 SUBSTITUTED CYCLOALKYL-4-OXONICOTINIC CARBOXAMIDES; GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORP (US) 2005-05-25 EP claimed
US-6448259-B1 CYCLOALKYL-4-OXONICOTINIC CARBOXAMIDES; AGONISTS, ANTAGONISTS OR INVERSE AGONISTS FOR GAMMA AMINOBUTYRIC ACID BINDING SITE, THE BENZODIAZEPINE RECEPTOR; ANXIETY, SLEEP AND SEIZURE DISORDERS SEDATIVE, ANXIOLYTIC AND ANTICONVULSANT ACTIVITY NEUROGEN CORPORATION 2002-09-10 US claimed
EP-1056724-A2 SUBSTITUTED CYCLOALKYL-4-OXONICOTINIC CARBOXAMIDES; GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 2000-12-06 EP claimed
WO-1999043661-A2 SUBSTITUTED CYCLOALKYL-4-OXONICOTINIC CARBOXAMIDES; GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1999-09-02 WO claimed
EP-1056724-B1 SUBSTITUTED CYCLOALKYL-4-OXONICOTINIC CARBOXAMIDES; GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORP (US) 2005-05-25 EP disclosed
US-6448259-B1 CYCLOALKYL-4-OXONICOTINIC CARBOXAMIDES; AGONISTS, ANTAGONISTS OR INVERSE AGONISTS FOR GAMMA AMINOBUTYRIC ACID BINDING SITE, THE BENZODIAZEPINE RECEPTOR; ANXIETY, SLEEP AND SEIZURE DISORDERS SEDATIVE, ANXIOLYTIC AND ANTICONVULSANT ACTIVITY NEUROGEN CORPORATION 2002-09-10 US disclosed
US-6194427-B1 BRAIN DISORDERS; PSYCHOLOGICAL DISORDERS; SLEEP DISORDERS; ANTICONVULSANTS NEUROGEN CORPORATION 2001-02-27 US disclosed