SCHEMBL6162307

SCHEMBL6162307

O=C(NCc1ccc(F)cc1)c1c[nH]c2c(c1=O)CCCCC2

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.54
ADORA1 P30542 1/20 0.54
ALDH1A1 P00352 4/20 0.49
MERTK Q12866 4/20 0.47
KMT2A Q03164 2/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2C19 P33261 1/20 0.46
LMNA P02545 3/20 0.45
MAPT P10636 1/20 0.45
RXFP1 Q9HBX9 1/20 0.45
KDM4E B2RXH2 2/20 0.43
MEN1 O00255 1/20 0.43
NPC1 O15118 1/20 0.43
POLB P06746 1/20 0.43
RECQL P46063 1/20 0.43
RAB9A P51151 1/20 0.43
MCL1 Q07820 1/20 0.43
CTDSP1 Q9GZU7 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
HPGD P15428 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6161944 0.99 ADORA2A (0.55) ADORA2AADORA1ALDH1A1MERTKKMT2A
SCHEMBL6162671 0.89 HPGD (0.55) ADORA2AADORA1ALDH1A1KMT2ALMNA
SCHEMBL6162507 0.88 ADORA2A (0.55) ADORA2AADORA1ALDH1A1KMT2ALMNA
SCHEMBL6160803 0.87 ADORA2A (0.55) ADORA2AADORA1ALDH1A1KMT2AMAPT
SCHEMBL6161991 0.87 ADORA2A (0.57) ADORA2AADORA1ALDH1A1LMNAMAPT
SCHEMBL6162309 0.86 LMNA (0.53) ADORA2AADORA1ALDH1A1LMNAMAPT
SCHEMBL6160996 0.85 ADORA2A (0.55) ADORA2AADORA1ALDH1A1KMT2ANPC1
SCHEMBL6162159 0.85 ADORA2A (0.57) ADORA2AADORA1ALDH1A1KMT2AMAPT
SCHEMBL6164599 0.84 ADORA2A (0.58) ADORA2AADORA1ALDH1A1KMT2AMAPT
SCHEMBL6162124 0.83 ADORA2A (0.45) ADORA2AADORA1ALDH1A1MAPTRXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1056724-B1 SUBSTITUTED CYCLOALKYL-4-OXONICOTINIC CARBOXAMIDES; GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORP (US) 2005-05-25 EP claimed
US-6448259-B1 CYCLOALKYL-4-OXONICOTINIC CARBOXAMIDES; AGONISTS, ANTAGONISTS OR INVERSE AGONISTS FOR GAMMA AMINOBUTYRIC ACID BINDING SITE, THE BENZODIAZEPINE RECEPTOR; ANXIETY, SLEEP AND SEIZURE DISORDERS SEDATIVE, ANXIOLYTIC AND ANTICONVULSANT ACTIVITY NEUROGEN CORPORATION 2002-09-10 US claimed
EP-1056724-B1 SUBSTITUTED CYCLOALKYL-4-OXONICOTINIC CARBOXAMIDES; GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORP (US) 2005-05-25 EP disclosed
US-6448259-B1 CYCLOALKYL-4-OXONICOTINIC CARBOXAMIDES; AGONISTS, ANTAGONISTS OR INVERSE AGONISTS FOR GAMMA AMINOBUTYRIC ACID BINDING SITE, THE BENZODIAZEPINE RECEPTOR; ANXIETY, SLEEP AND SEIZURE DISORDERS SEDATIVE, ANXIOLYTIC AND ANTICONVULSANT ACTIVITY NEUROGEN CORPORATION 2002-09-10 US disclosed
US-6194427-B1 BRAIN DISORDERS; PSYCHOLOGICAL DISORDERS; SLEEP DISORDERS; ANTICONVULSANTS NEUROGEN CORPORATION 2001-02-27 US disclosed